Drug profile

The FDA adverse-event record for Carprofen (Unknown)

491 FDA reports name Carprofen (Unknown), a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#305 of 2,679
by report volume (all drugs)
491
adverse-event reports
6.5%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Carprofen (Unknown) ranks #305 of 2679 by total reports (491) and #715 of 1130 by death-coded share (6.5%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#305
This drug, reports of 2679
#715
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Carprofen (Unknown) has 491 reports now versus 489 in that prior snapshot: 2 more (0.4%).

Report change
+2
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Carprofen (Unknown) changes

Signature read: 491 reports place Carprofen (Unknown) in the upper third of FDA AER volume (#305 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
491
Total Reports
32
Deaths Reported
6.5%
Death-coded share of reports

Active Ingredients

Carprofen (Unknown)

Administration Routes

OralUnknownParenteralSubcutaneousRectal

Species Affected

Dog 491

Most Affected Breeds

Retriever - Labrador 103
Shepherd Dog - German 25
Retriever - Golden 24
Pit Bull 24
Crossbred Canine/dog 22
Shepherd Dog - Australian 17
Beagle 14
Shih Tzu 13
Dachshund (unspecified) 11
Boxer (German Boxer) 10

Most Reported Reactions

Vomiting 106
Emesis 74
Lethargy (see also Central nervous system depression in 'Neurological') 54
Diarrhoea 50
Lack of efficacy - NOS 48
Elevated alanine aminotransferase (ALT) 31
Seizure NOS 29
Other abnormal test result NOS 28
Not eating 24
Elevated serum alkaline phosphatase (SAP) 23
Anorexia 22
Behavioural disorder NOS 18

Outcome Breakdown

Recovered/Normal
180 (36.7%)
Outcome Unknown
158 (32.2%)
Ongoing
104 (21.2%)
Recovered with Sequela
17 (3.5%)
Euthanized
17 (3.5%)
Died
15 (3.1%)

Carprofen (Unknown): high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Carprofen (Unknown), both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (6.5% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Carprofen (Unknown) (#305 of 2,679 by report volume); death-coded 6.5%. PlainBreed drug row · report volume stamp 491 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →