Drug profile

The FDA adverse-event record for Imidacloprid And Moxidectin

488 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Imidacloprid And Moxidectin. See the species affected, top reactions, and outcomes below.

488
adverse-event reports
2.5%
death-coded share
Dog
most-reported species
89
Lethargy (see also Central nervous system depression in 'Neurological') - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
488
Total Reports
12
Deaths Reported
2.5%
Death Rate

Active Ingredients

Imidacloprid And Moxidectin

Administration Routes

TopicalOralUnknownOtherOphthalmic

Species Affected

Dog 303
Cat 164
Human 14
Unknown 6
Rabbit 1

Most Affected Breeds

Domestic Shorthair 101
Mixed (Dog) 42
Unknown 21
Domestic Longhair 20
Terrier - Yorkshire 19
Retriever - Labrador 19
Dog (unknown) 18
Cat (unknown) 17
Chihuahua 17
Maltese 14

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 89
Pruritus 67
Vomiting 61
Behavioural disorder NOS 61
Ataxia 54
Other abnormal test result NOS 41
Hypersalivation 36
Diarrhoea 29
Muscle tremor 28
Application site alopecia 23
Inappetence 21
Anorexia 20

Outcome Breakdown

Outcome Unknown
242 (50.2%)
Recovered/Normal
220 (45.6%)
Died
8 (1.7%)
Ongoing
7 (1.5%)
Euthanized
4 (0.8%)
Recovered with Sequela
1 (0.2%)

Imidacloprid And Moxidectin Adverse Event Insights

488 reports name Imidacloprid And Moxidectin; 12 recorded a death outcome (2.5% of reported events, not a population-level mortality rate). Active ingredient: Imidacloprid And Moxidectin. Administration routes: Topical, Oral, Unknown, Other.

By species: Dog (303 reports), Cat (164 reports), Human (14 reports). By breed: Domestic Shorthair (101), Mixed (Dog) (42), Unknown (21).

Leading clinical signs: Lethargy (see also Central nervous system depression in 'Neurological') (89), Pruritus (67), Vomiting (61), Behavioural disorder NOS (61). Outcome, 482 coded reports: Outcome Unknown leads at 50.2%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.