Drug profile

The FDA adverse-event record for Emodepside, Praziquantel

306 FDA reports name Emodepside, Praziquantel, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#415 of 2,679
by report volume (all drugs)
306
adverse-event reports
6.5%
death-coded share
Cat
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Emodepside, Praziquantel ranks #415 of 2679 by total reports (306) and #713 of 1130 by death-coded share (6.5%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#415
This drug, reports of 2679
#713
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Emodepside, Praziquantel has 306 reports now versus 305 in that prior snapshot: 1 more (0.3%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Emodepside, Praziquantel changes

Signature read: 306 reports place Emodepside, Praziquantel in the upper third of FDA AER volume (#415 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
306
Total Reports
20
Deaths Reported
6.5%
Death-coded share of reports

Active Ingredients

Emodepside, Praziquantel

Administration Routes

TopicalOralUnknownOther

Species Affected

Cat 300
Human 3
Unknown 2
Dog 1

Most Affected Breeds

Domestic (unspecified) 263
Cat (unknown) 18
Unknown 5
Siamese 4
Himalayan 4
Maine Coon 2
Domestic Shorthair 2
Manx 1
Ragdoll 1
Russian 1

Most Reported Reactions

Application site alopecia 86
Hypersalivation 81
Depression 50
Vomiting 49
Anorexia 45
Ataxia 28
Application site pruritus 25
Trembling 21
Application site inflammation 21
Diarrhoea 18
Application site erythema 17
Death 15

Outcome Breakdown

Died
20 (83.3%)
Ongoing
2 (8.3%)
Recovered/Normal
1 (4.2%)
Outcome Unknown
1 (4.2%)

Emodepside, Praziquantel: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Emodepside, Praziquantel, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (6.5% here), distinct from the volume row.

What to do with this drug

  • Compare Emodepside, Praziquantel's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Emodepside, Praziquantel (#415 of 2,679 by report volume); death-coded 6.5%. PlainBreed drug row · report volume stamp 306 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →