Drug profile

The FDA adverse-event record for Bupivacaine Lipsome Injectable Suspension

153 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Bupivacaine Lipsome Injectable Suspension. See the species affected, top reactions, and outcomes below.

153
adverse-event reports
6.5%
death-coded share
Dog
most-reported species
37
Product problem - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
153
Total Reports
10
Deaths Reported
6.5%
Death Rate

Active Ingredients

Bupivacaine Lipsome Injectable Suspension

Administration Routes

IntralesionalUnknownOphthalmicSubcutaneousIntraspinalIntra-gingivalOral

Species Affected

Dog 90
Unknown 46
Human 8
Cat 6
Horse 2
Chinchilla 1

Most Affected Breeds

Unknown 55
Dog (unknown) 29
Retriever - Labrador 8
Crossbred Canine/dog 7
Pit Bull 6
Shepherd Dog - German 4
Boxer (German Boxer) 4
Mixed (Dog) 4
Cat (unknown) 3
Mastiff 2

Most Reported Reactions

Product problem 37
Vials, Damaged 22
Injection site swelling 13
Injection site infection 13
Injection site seroma 12
Application site serosanguinous discharge 9
Other abnormal test result NOS 9
Injection site serosanguinous discharge 9
Death 8
Injection site bruising 7
Stopper, abnormal 7
Injection site serous discharge 5

Outcome Breakdown

Outcome Unknown
49 (45.8%)
Recovered/Normal
48 (44.9%)
Died
8 (7.5%)
Euthanized
2 (1.9%)

Bupivacaine Lipsome Injectable Suspension Adverse Event Insights

153 reports name Bupivacaine Lipsome Injectable Suspension; 10 recorded a death outcome (6.5% of reported events, not a population-level mortality rate). Active ingredient: Bupivacaine Lipsome Injectable Suspension. Administration routes: Intralesional, Unknown, Ophthalmic, Subcutaneous.

By species: Dog (90 reports), Unknown (46 reports), Human (8 reports). By breed: Unknown (55), Dog (unknown) (29), Retriever - Labrador (8).

Leading clinical signs: Product problem (37), Vials, Damaged (22), Injection site swelling (13), Injection site infection (13). Outcome, 107 coded reports: Outcome Unknown leads at 45.8%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.