Drug profile

The FDA adverse-event record for Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate

448 FDA reports name Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#328 of 2,679
by report volume (all drugs)
448
adverse-event reports
5.8%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate ranks #328 of 2679 by total reports (448) and #745 of 1130 by death-coded share (5.8%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#328
This drug, reports of 2679
#745
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate has 448 reports now versus 441 in that prior snapshot: 7 more (1.6%).

Report change
+7
Death-coded reports
+1
Death-coded share
+0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate changes

Signature read: 448 reports place Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate in the upper third of FDA AER volume (#328 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
448
Total Reports
26
Deaths Reported
5.8%
Death-coded share of reports

Active Ingredients

Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate

Administration Routes

OralUnknown

Species Affected

Dog 425
Cat 23

Most Affected Breeds

Retriever - Labrador 99
Retriever - Golden 33
Crossbred Canine/dog 19
Shepherd Dog - German 17
Pit Bull 14
Domestic Shorthair 13
Shepherd Dog - Australian 11
Beagle 9
Collie - Border 9
Spaniel - Cocker American 8

Most Reported Reactions

Vomiting 119
Diarrhoea 73
Lethargy (see also Central nervous system depression in 'Neurological') 57
Lack of efficacy - NOS 41
Other abnormal test result NOS 34
Elevated alanine aminotransferase (ALT) 34
Elevated serum alkaline phosphatase (SAP) 33
Decreased appetite 33
Not eating 30
Weight loss 23
Seizure NOS 23
Bloody diarrhoea 23

Outcome Breakdown

Ongoing
149 (33.3%)
Outcome Unknown
143 (31.9%)
Recovered/Normal
127 (28.3%)
Euthanized
19 (4.2%)
Died
7 (1.6%)
Recovered with Sequela
3 (0.7%)

Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate: low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

  • Compare Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate (#328 of 2,679 by report volume); death-coded 5.8%. PlainBreed drug row · report volume stamp 448 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →