Drug profile

The FDA adverse-event record for Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate

438 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate. See the species affected, top reactions, and outcomes below.

438
adverse-event reports
5.7%
death-coded share
Dog
most-reported species
116
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
438
Total Reports
25
Deaths Reported
5.7%
Death Rate

Active Ingredients

Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate

Administration Routes

OralUnknown

Species Affected

Dog 418
Cat 20

Most Affected Breeds

Retriever - Labrador 98
Retriever - Golden 33
Crossbred Canine/dog 19
Shepherd Dog - German 17
Pit Bull 14
Domestic Shorthair 12
Shepherd Dog - Australian 11
Beagle 9
Collie - Border 9
Spaniel - Cocker American 8

Most Reported Reactions

Vomiting 116
Diarrhoea 71
Lethargy (see also Central nervous system depression in 'Neurological') 57
Lack of efficacy - NOS 41
Other abnormal test result NOS 33
Elevated alanine aminotransferase (ALT) 33
Elevated serum alkaline phosphatase (SAP) 33
Decreased appetite 31
Not eating 28
Bloody diarrhoea 23
Behavioural disorder NOS 22
Seizure NOS 22

Outcome Breakdown

Ongoing
145 (33.1%)
Outcome Unknown
139 (31.7%)
Recovered/Normal
126 (28.8%)
Euthanized
19 (4.3%)
Died
6 (1.4%)
Recovered with Sequela
3 (0.7%)

Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate Adverse Event Insights

438 reports name Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate; 25 recorded a death outcome (5.7% of reported events, not a population-level mortality rate). Active ingredient: Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate. Administration routes: Oral, Unknown.

By species: Dog (418 reports), Cat (20 reports). By breed: Retriever - Labrador (98), Retriever - Golden (33), Crossbred Canine/dog (19).

Leading clinical signs: Vomiting (116), Diarrhoea (71), Lethargy (see also Central nervous system depression in 'Neurological') (57), Lack of efficacy - NOS (41). Outcome, 438 coded reports: Ongoing leads at 33.1%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.