Drug profile

The FDA adverse-event record for Ivermectin 136Mcg, Pyrantel 114Mg

450 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Ivermectin 136Mcg, Pyrantel 114Mg. See the species affected, top reactions, and outcomes below.

450
adverse-event reports
1.3%
death-coded share
Dog
most-reported species
191
INEFFECTIVE, HEARTWORM LARVAE - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
450
Total Reports
6
Deaths Reported
1.3%
Death Rate

Active Ingredients

Ivermectin 136Mcg, Pyrantel 114Mg

Administration Routes

OralUnknown

Species Affected

Dog 419
Unknown 29
Human 1
Cat 1

Most Affected Breeds

Crossbred Canine/dog 48
Retriever - Labrador 47
Beagle 45
Unknown 30
Shepherd Dog - German 20
Spaniel - Cocker American 17
Collie - Border 15
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 13
Sheepdog - Shetland 11
Dog (unknown) 11

Most Reported Reactions

INEFFECTIVE, HEARTWORM LARVAE 191
Vomiting 82
Lack of efficacy (endoparasite) - hookworm 62
Lack of efficacy - NOS 59
Diarrhoea 36
INEFFECTIVE, ASCARIDS NOS 35
Drug dose administration interval too long 27
Lethargy (see also Central nervous system depression in 'Neurological') 25
Underfilling, Package 18
Underdose 18
Drug dose omission 16
Uncoded sign 15

Outcome Breakdown

Outcome Unknown
252 (59.9%)
Recovered/Normal
133 (31.6%)
Recovered with Sequela
19 (4.5%)
Ongoing
11 (2.6%)
Died
6 (1.4%)

Ivermectin 136Mcg, Pyrantel 114Mg Adverse Event Insights

450 reports name Ivermectin 136Mcg, Pyrantel 114Mg; 6 recorded a death outcome (1.3% of reported events, not a population-level mortality rate). Active ingredient: Ivermectin 136Mcg, Pyrantel 114Mg. Administration routes: Oral, Unknown.

By species: Dog (419 reports), Unknown (29 reports), Human (1 reports). By breed: Crossbred Canine/dog (48), Retriever - Labrador (47), Beagle (45).

Leading clinical signs: INEFFECTIVE, HEARTWORM LARVAE (191), Vomiting (82), Lack of efficacy (endoparasite) - hookworm (62), Lack of efficacy - NOS (59). Outcome, 421 coded reports: Outcome Unknown leads at 59.9%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.