Drug profile

The FDA adverse-event record for Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Modified Live Virus

442 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Modified Live Virus. See the species affected, top reactions, and outcomes below.

442
adverse-event reports
9.5%
death-coded share
Dog
most-reported species
162
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
442
Total Reports
42
Deaths Reported
9.5%
Death Rate

Active Ingredients

Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Modified Live Virus

Administration Routes

SubcutaneousParenteralUnknownOralOtherSubconjunctival

Species Affected

Dog 442

Most Affected Breeds

Retriever - Labrador 49
Retriever - Golden 38
Chihuahua 25
Shih Tzu 22
Shepherd Dog - Australian 22
Dachshund (unspecified) 14
Pug 14
Terrier - Yorkshire 13
Shepherd Dog - German 12
Boxer (German Boxer) 12

Most Reported Reactions

Vomiting 162
Diarrhoea 60
Lethargy (see also Central nervous system depression in 'Neurological') 55
Facial swelling (see also 'Skin') 46
Other abnormal test result NOS 43
Lack of efficacy (virus) - parvovirus (including feline panleukopenia) 41
Anaphylaxis 39
Death 32
Lethargy (see also Central nervous system depression in Neurological) 31
Pale mucous membrane 29
Not eating 29
Facial swelling (see also Skin) 22

Outcome Breakdown

Recovered/Normal
176 (39.7%)
Outcome Unknown
148 (33.4%)
Ongoing
77 (17.4%)
Died
35 (7.9%)
Euthanized
7 (1.6%)

Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Modified Live Virus Adverse Event Insights

442 reports name Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Modified Live Virus; 42 recorded a death outcome (9.5% of reported events, not a population-level mortality rate). Active ingredient: Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Modified Live Virus. Administration routes: Subcutaneous, Parenteral, Unknown, Oral.

By species: Dog (442 reports). By breed: Retriever - Labrador (49), Retriever - Golden (38), Chihuahua (25).

Leading clinical signs: Vomiting (162), Diarrhoea (60), Lethargy (see also Central nervous system depression in 'Neurological') (55), Facial swelling (see also 'Skin') (46). Outcome, 443 coded reports: Recovered/Normal leads at 39.7%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.