Bovine Parainfluenza Virus 3 (Ts), Rlb103 (Nl-Bk-6), Mlv; Bovine Respiratory Syn

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448 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
448
Total Reports
381
Deaths Reported
8500.0%
Death Rate

Active Ingredients

Bovine Parainfluenza Virus 3 (Ts), Rlb103 (Nl-Bk-6), Mlv; Bovine Respiratory Syn

Administration Routes

UnknownNasalSubcutaneousIntramuscularOral

Species Affected

Cattle 445
Unknown 3

Most Affected Breeds

Cattle (other) 226
Mixed (Cattle) 115
Holstein-Friesian also known as Holstein 54
Crossbred Bovine/Cattle 17
Aberdeen Angus 16
Cattle (unknown) 6
Unknown 3
Jersey 3
Hereford cattle 2
Brangus 2

Most Reported Reactions

Lack of efficacy (bacteria) - NOS 267
Death 243
Lack of efficacy - NOS 130
Abnormal test result 51
Unrelated death 46
CULTURE/TITER DATA ABNORMAL 40
Abnormal necropsy finding 34
Increased mortality rate 32
Other abnormal test result NOS 28
NT - Abnormal necropsy finding NOS 23
Death by euthanasia 20
PR-LUNG(S), LESION(S) 16

Outcome Breakdown

Died
373 (48.4%)
Outcome Unknown
278 (36.1%)
Recovered/Normal
48 (6.2%)
Ongoing
45 (5.8%)
Euthanized
15 (1.9%)
Recovered with Sequela
11 (1.4%)

Data Summary

Metric Value
Total adverse event reports 448
Reports involving death 381
Case-fatality rate (reported events) 8500.0%
Distinct species in reports 2
Distinct breeds in reports 14
Distinct reactions reported 20
Active ingredients on file 1

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER). Counts reflect voluntary reports only.

Bovine Parainfluenza Virus 3 (Ts), Rlb103 (Nl-Bk-6), Mlv; Bovine Respiratory Syn Adverse Event Insights

The FDA Center for Veterinary Medicine database currently holds 448 adverse event reports referencing Bovine Parainfluenza Virus 3 (Ts), Rlb103 (Nl-Bk-6), Mlv; Bovine Respiratory Syn, including 381 reports in which the animal died — a 8500.0% case-fatality figure among reported events only, not a population-level mortality rate. Active ingredient on file: Bovine Parainfluenza Virus 3 (Ts), Rlb103 (Nl-Bk-6), Mlv; Bovine Respiratory Syn. Reported administration routes include Unknown, Nasal, Subcutaneous, Intramuscular. These numbers reflect voluntary submissions from pet owners, veterinarians, and manufacturers and therefore under-represent mild events and over-represent severe ones — a pattern the FDA has documented repeatedly for pharmacovigilance datasets.

The species most frequently named in Bovine Parainfluenza Virus 3 (Ts), Rlb103 (Nl-Bk-6), Mlv; Bovine Respiratory Syn reports are Cattle (445 reports), Unknown (3 reports), with Cattle accounting for the largest share. Within those species, Cattle (other) (226), Mixed (Cattle) (115), Holstein-Friesian also known as Holstein (54) appear most often — though breed popularity and ownership density shape these counts as much as any drug-specific sensitivity. This distribution matters because the same active ingredient can behave very differently across body sizes, ages, and species physiology.

The most commonly reported clinical signs associated with Bovine Parainfluenza Virus 3 (Ts), Rlb103 (Nl-Bk-6), Mlv; Bovine Respiratory Syn are Lack of efficacy (bacteria) - NOS (267), Death (243), Lack of efficacy - NOS (130), Abnormal test result (51). Of the 770 reports with a coded outcome, Died is the leading category at 48.4%. Because FDA adverse event data describes correlation rather than causation, these figures are best used to frame informed questions with a veterinarian and to compare reporting patterns across related products — not as a standalone safety verdict on Bovine Parainfluenza Virus 3 (Ts), Rlb103 (Nl-Bk-6), Mlv; Bovine Respiratory Syn.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial