Drug profile

The FDA adverse-event record for Acetylsalicylic Acid

171 FDA reports name Acetylsalicylic Acid, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#576 of 2,679
by report volume (all drugs)
171
adverse-event reports
36.3%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Acetylsalicylic Acid ranks #576 of 2679 by total reports (171) and #96 of 1130 by death-coded share (36.3%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#576
This drug, reports of 2679
#96
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Acetylsalicylic Acid has 171 reports now versus 171 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Acetylsalicylic Acid changes

Signature read: death-coded report count at 62 is the most distinctive stamp on Acetylsalicylic Acid's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
171
Total Reports
62
Deaths Reported
36.3%
Death-coded share of reports

Active Ingredients

Acetylsalicylic Acid

Administration Routes

OralUnknown

Species Affected

Dog 155
Cat 8
Human 7
Horse 1

Most Affected Breeds

Retriever - Labrador 35
Shepherd Dog - German 8
Dachshund (unspecified) 7
Rottweiler 7
Unknown 7
Retriever - Golden 6
Domestic Shorthair 6
Shepherd Dog - Australian 5
Terrier - Bull - American Pit 5
Terrier - Yorkshire 5

Most Reported Reactions

Vomiting 53
Lethargy (see also Central nervous system depression in 'Neurological') 53
Anorexia 35
Death 31
Death by euthanasia 27
Elevated serum alkaline phosphatase (SAP) 24
Diarrhoea 24
Other abnormal test result NOS 22
Elevated alanine aminotransferase (ALT) 21
Elevated total bilirubin 21
Elevated liver enzymes 20
Anaemia NOS 16

Outcome Breakdown

Ongoing
65 (37.8%)
Died
35 (20.3%)
Euthanized
27 (15.7%)
Recovered/Normal
26 (15.1%)
Outcome Unknown
19 (11.0%)

Acetylsalicylic Acid: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Acetylsalicylic Acid, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Acetylsalicylic Acid (#576 of 2,679 by report volume); death-coded 36.3%. PlainBreed drug row · death-coded report count stamp 62 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →