Drug profile

The FDA adverse-event record for Pain Relief Medication Unknown

106 FDA reports name Pain Relief Medication Unknown, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#761 of 2,679
by report volume (all drugs)
106
adverse-event reports
35.8%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Pain Relief Medication Unknown ranks #761 of 2679 by total reports (106) and #98 of 1130 by death-coded share (35.8%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#761
This drug, reports of 2679
#98
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Pain Relief Medication Unknown has 106 reports now versus 106 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Pain Relief Medication Unknown changes

Signature read: Pain Relief Medication Unknown's 35.8% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
106
Total Reports
38
Deaths Reported
35.8%
Death-coded share of reports

Active Ingredients

Pain Relief Medication Unknown

Administration Routes

UnknownOralTopicalOphthalmic

Species Affected

Dog 69
Cat 37

Most Affected Breeds

Domestic Shorthair 16
Retriever - Labrador 9
Domestic Longhair 7
Shih Tzu 4
Cat (other) 4
Chihuahua 3
Terrier - Bull - American Pit 3
Maltese 2
Terrier - Yorkshire 2
Terrier - Boston 2

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 39
Death 22
Anorexia 22
Vomiting 21
Death by euthanasia 15
Fever 14
Diarrhoea 13
Weight loss 11
Adipsia 11
Leucocytosis NOS 10
Anaemia NOS 10
Not eating 8

Outcome Breakdown

Ongoing
36 (34.0%)
Died
24 (22.6%)
Outcome Unknown
24 (22.6%)
Euthanized
14 (13.2%)
Recovered/Normal
8 (7.5%)

Pain Relief Medication Unknown: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Pain Relief Medication Unknown, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (35.8% here), distinct from the volume row.

What to do with this drug

  • Compare Pain Relief Medication Unknown's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Pain Relief Medication Unknown (#761 of 2,679 by report volume); death-coded 35.8%. PlainBreed drug row · death-coded share stamp 35.8% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →