Drug profile

The FDA adverse-event record for Canine Distemper-Adenovirus Type 2-Parvovirus Vaccine, Modified Live Virus

171 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Canine Distemper-Adenovirus Type 2-Parvovirus Vaccine, Modified Live Virus. See the species affected, top reactions, and outcomes below.

171
adverse-event reports
5.3%
death-coded share
Dog
most-reported species
54
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
171
Total Reports
9
Deaths Reported
5.3%
Death Rate

Active Ingredients

Canine Distemper-Adenovirus Type 2-Parvovirus Vaccine, Modified Live Virus

Administration Routes

SubcutaneousParenteralUnknownSubconjunctivalOther

Species Affected

Dog 171

Most Affected Breeds

Retriever - Labrador 15
Chihuahua 13
Shepherd Dog - Australian 10
Maltese 8
Retriever - Golden 8
Shih Tzu 7
Bulldog - French 7
Terrier - Boston 6
Terrier - Yorkshire 5
Pug 5

Most Reported Reactions

Vomiting 54
Diarrhoea 21
Lack of efficacy (virus) - parvovirus (including feline panleukopenia) 21
Lethargy (see also Central nervous system depression in 'Neurological') 18
Other abnormal test result NOS 17
Facial swelling (see also 'Skin') 13
Anaphylaxis 9
Fever 8
Lethargy (see also Central nervous system depression in Neurological) 8
Not eating 7
Facial swelling (see also Skin) 7
Emesis (multiple) 6

Outcome Breakdown

Recovered/Normal
68 (39.8%)
Outcome Unknown
66 (38.6%)
Ongoing
28 (16.4%)
Died
5 (2.9%)
Euthanized
4 (2.3%)

Canine Distemper-Adenovirus Type 2-Parvovirus Vaccine, Modified Live Virus Adverse Event Insights

171 reports name Canine Distemper-Adenovirus Type 2-Parvovirus Vaccine, Modified Live Virus; 9 recorded a death outcome (5.3% of reported events, not a population-level mortality rate). Active ingredient: Canine Distemper-Adenovirus Type 2-Parvovirus Vaccine, Modified Live Virus. Administration routes: Subcutaneous, Parenteral, Unknown, Subconjunctival.

By species: Dog (171 reports). By breed: Retriever - Labrador (15), Chihuahua (13), Shepherd Dog - Australian (10).

Leading clinical signs: Vomiting (54), Diarrhoea (21), Lack of efficacy (virus) - parvovirus (including feline panleukopenia) (21), Lethargy (see also Central nervous system depression in 'Neurological') (18). Outcome, 171 coded reports: Recovered/Normal leads at 39.8%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.