Drug profile

The FDA adverse-event record for Acetaminophen

59 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Acetaminophen. See the species affected, top reactions, and outcomes below.

59
adverse-event reports
23.7%
death-coded share
Dog
most-reported species
10
Death by euthanasia - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
59
Total Reports
14
Deaths Reported
23.7%
Death Rate

Active Ingredients

Acetaminophen

Administration Routes

OralUnknown

Species Affected

Dog 49
Human 10

Most Affected Breeds

Retriever - Labrador 17
Unknown 10
Bulldog 3
Retriever - Golden 3
Poodle - Standard 3
Shepherd Dog - Australian 3
Terrier - Bull - American Pit 2
Bulldog - American 2
Shar Pei 2
Dog (unknown) 1

Most Reported Reactions

Death by euthanasia 10
Lethargy (see also Central nervous system depression in 'Neurological') 8
Vomiting 7
Weakness 7
Lack of efficacy - NOS 7
Abnormal radiograph finding 7
Lethargy (see also Central nervous system depression in Neurological) 7
Anaemia NOS 6
Diarrhoea 6
Accidental exposure 6
Elevated alanine aminotransferase (ALT) 6
Ataxia 6

Outcome Breakdown

Outcome Unknown
20 (33.9%)
Ongoing
14 (23.7%)
Recovered/Normal
11 (18.6%)
Euthanized
10 (16.9%)
Died
4 (6.8%)

Acetaminophen Adverse Event Insights

59 reports name Acetaminophen; 14 recorded a death outcome (23.7% of reported events, not a population-level mortality rate). Active ingredient: Acetaminophen. Administration routes: Oral, Unknown.

By species: Dog (49 reports), Human (10 reports). By breed: Retriever - Labrador (17), Unknown (10), Bulldog (3).

Leading clinical signs: Death by euthanasia (10), Lethargy (see also Central nervous system depression in 'Neurological') (8), Vomiting (7), Weakness (7). Outcome, 59 coded reports: Outcome Unknown leads at 33.9%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.