Drug profile

The FDA adverse-event record for Benazepril Hydrochloride + Spironolactone

63 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Benazepril Hydrochloride + Spironolactone. See the species affected, top reactions, and outcomes below.

63
adverse-event reports
4.8%
death-coded share
Dog
most-reported species
12
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
63
Total Reports
3
Deaths Reported
4.8%
Death Rate

Active Ingredients

Benazepril HydrochlorideSpironolactone

Administration Routes

OralUnknown

Species Affected

Dog 42
Unknown 21

Most Affected Breeds

Unknown 21
Beagle 11
Crossbred Canine/dog 5
Chihuahua 5
Mixed (Dog) 3
Retriever - Golden 2
Spaniel - Cocker American 2
Shih Tzu 2
Spaniel - King Charles Cavalier 2
Spitz - German Pomeranian 1

Most Reported Reactions

Vomiting 12
Tablets, Abnormal 7
Diarrhoea 6
Loose stool 5
Closure, Abnormal 5
Product defect, product difficult to use/handle (see also 'Drug device difficult to use/handle') 5
Anorexia 4
Lack of efficacy - NOS 4
Difficulty of Use 4
Emesis 3
Appearance, Abnormal 3
Caps, Abnormal 3

Outcome Breakdown

Recovered/Normal
23 (54.8%)
Ongoing
12 (28.6%)
Outcome Unknown
4 (9.5%)
Died
2 (4.8%)
Euthanized
1 (2.4%)

Benazepril Hydrochloride + Spironolactone Adverse Event Insights

63 reports name Benazepril Hydrochloride + Spironolactone; 3 recorded a death outcome (4.8% of reported events, not a population-level mortality rate). Active ingredients: Benazepril Hydrochloride, Spironolactone. Administration routes: Oral, Unknown.

By species: Dog (42 reports), Unknown (21 reports). By breed: Unknown (21), Beagle (11), Crossbred Canine/dog (5).

Leading clinical signs: Vomiting (12), Tablets, Abnormal (7), Diarrhoea (6), Loose stool (5). Outcome, 42 coded reports: Recovered/Normal leads at 54.8%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.