Drug profile

The FDA adverse-event record for Cobalamin

46 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Cobalamin. See the species affected, top reactions, and outcomes below.

46
adverse-event reports
23.9%
death-coded share
Dog
most-reported species
9
Weight loss - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
46
Total Reports
11
Deaths Reported
23.9%
Death Rate

Active Ingredients

Cobalamin

Administration Routes

UnknownOralParenteralSubcutaneousIntravenous

Species Affected

Dog 25
Cat 21

Most Affected Breeds

Domestic Shorthair 11
Retriever - Labrador 6
Domestic Longhair 3
Bulldog - English 3
Retriever - Nova Scotia Duck Tolling 2
Maine Coon 2
Crossbred Canine/dog 2
Terrier - Bull - American Pit 2
Poodle - Miniature 1
Bolognese 1

Most Reported Reactions

Weight loss 9
Diarrhoea 9
Vomiting 7
Anorexia 6
Death by euthanasia 6
Decreased appetite 5
Death 5
Not eating 5
Lethargy (see also Central nervous system depression in 'Neurological') 4
Behavioural disorder NOS 4
Elevated alanine aminotransferase (ALT) 4
Lethargy (see also Central nervous system depression in Neurological) 4

Outcome Breakdown

Ongoing
16 (34.8%)
Outcome Unknown
11 (23.9%)
Recovered/Normal
7 (15.2%)
Euthanized
6 (13.0%)
Died
5 (10.9%)
Recovered with Sequela
1 (2.2%)

Cobalamin Adverse Event Insights

46 reports name Cobalamin; 11 recorded a death outcome (23.9% of reported events, not a population-level mortality rate). Active ingredient: Cobalamin. Administration routes: Unknown, Oral, Parenteral, Subcutaneous.

By species: Dog (25 reports), Cat (21 reports). By breed: Domestic Shorthair (11), Retriever - Labrador (6), Domestic Longhair (3).

Leading clinical signs: Weight loss (9), Diarrhoea (9), Vomiting (7), Anorexia (6). Outcome, 46 coded reports: Ongoing leads at 34.8%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.