Glucosamine And Chondroitin

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65 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
65
Total Reports
8
Deaths Reported
1230.0%
Death Rate

Active Ingredients

Glucosamine And Chondroitin

Administration Routes

UnknownOral

Species Affected

Dog 57
Cat 7
Horse 1

Most Affected Breeds

Retriever - Labrador 13
Domestic Shorthair 7
Siberian Husky 4
Chihuahua 3
Shepherd Dog - German 3
Unknown 2
Shih Tzu 2
Newfoundland 2
Rottweiler 2
Collie - Border 2

Most Reported Reactions

Vomiting 15
Lack of efficacy - NOS 11
Elevated alanine aminotransferase (ALT) 9
Death by euthanasia 7
Lethargy (see also Central nervous system depression in 'Neurological') 7
Diarrhoea 7
Elevated serum alkaline phosphatase (SAP) 6
Not eating 6
Behavioural disorder NOS 5
Polyuria 5
Limb weakness 4
Inappetence 3

Outcome Breakdown

Ongoing
23 (35.4%)
Outcome Unknown
18 (27.7%)
Recovered/Normal
16 (24.6%)
Euthanized
7 (10.8%)
Died
1 (1.5%)

Data Summary

Metric Value
Total adverse event reports 65
Reports involving death 8
Case-fatality rate (reported events) 1230.0%
Distinct species in reports 3
Distinct breeds in reports 20
Distinct reactions reported 20
Active ingredients on file 1

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER). Counts reflect voluntary reports only.

Glucosamine And Chondroitin Adverse Event Insights

The FDA Center for Veterinary Medicine database currently holds 65 adverse event reports referencing Glucosamine And Chondroitin, including 8 reports in which the animal died — a 1230.0% case-fatality figure among reported events only, not a population-level mortality rate. Active ingredient on file: Glucosamine And Chondroitin. Reported administration routes include Unknown, Oral. These numbers reflect voluntary submissions from pet owners, veterinarians, and manufacturers and therefore under-represent mild events and over-represent severe ones — a pattern the FDA has documented repeatedly for pharmacovigilance datasets.

The species most frequently named in Glucosamine And Chondroitin reports are Dog (57 reports), Cat (7 reports), Horse (1 reports), with Dog accounting for the largest share. Within those species, Retriever - Labrador (13), Domestic Shorthair (7), Siberian Husky (4) appear most often — though breed popularity and ownership density shape these counts as much as any drug-specific sensitivity. This distribution matters because the same active ingredient can behave very differently across body sizes, ages, and species physiology.

The most commonly reported clinical signs associated with Glucosamine And Chondroitin are Vomiting (15), Lack of efficacy - NOS (11), Elevated alanine aminotransferase (ALT) (9), Death by euthanasia (7). Of the 65 reports with a coded outcome, Ongoing is the leading category at 35.4%. Because FDA adverse event data describes correlation rather than causation, these figures are best used to frame informed questions with a veterinarian and to compare reporting patterns across related products — not as a standalone safety verdict on Glucosamine And Chondroitin.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial