Reaction profile

The FDA adverse-event record for pale mucous membrane

6,028 FDA adverse-event reports reference pale mucous membrane (VeDDRA 222). See the species, breeds, and drugs most associated with it below.

6,028
reports citing this reaction
28.1%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
6,028
Total Reports
1,695
Deaths
28.1%
Death Rate

Species Most Affected

Dog 5,224
Cat 687
Horse 81
Cattle 17
Goat 7
Rabbit 3
Other Canids 2
Ferret 2
Pig 2
Fish 1

Breeds Most Affected

Retriever - Labrador 391
Crossbred Canine/dog 346
Domestic Shorthair 346
Shih Tzu 277
Chihuahua 238
Boxer (German Boxer) 217
Terrier - Yorkshire 209
Terrier - Bull - American Pit 181
Retriever - Golden 170
Maltese 140

Associated Drugs

Moxidectin 1,531
Maropitant Citrate 490
Carprofen 468
Milbemycin Oxime + Spinosad 349
Cefovecin 231
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 230
Rabies Virus, 217
Afoxolaner 193
Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 192
Bedinvetmab 191
Dexamethasone 188
Prednisone 187
Diphenhydramine Hcl 185
Melarsomine Dihydrochloride 183
Rabies Virus, Kv 182
Dexmedetomidine Hydrochloride 164
Spinosad 159
Gabapentin 150
Oclacitinib Maleate 150
Famotidine 133

Pale mucous membrane Reaction Insights

6,028 reports name Pale mucous membrane; 1,695 recorded a death outcome (28.1% of reported events, not a population-level mortality rate). VeDDRA code: 222.

By species: Dog (5,224 reports), Cat (687 reports), Horse (81 reports). By breed: Retriever - Labrador (391), Crossbred Canine/dog (346), Domestic Shorthair (346).

Most co-reported drugs: Moxidectin (1,531 reports), Maropitant Citrate (490 reports), Carprofen (468 reports), Milbemycin Oxime + Spinosad (349 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.