Reaction profile

The FDA adverse-event record for uncontrolled diabetes

115 FDA adverse-event reports reference uncontrolled diabetes (VeDDRA 388). See the species, breeds, and drugs most associated with it below.

115
reports citing this reaction
20.9%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
115
Total Reports
24
Deaths
20.9%
Death Rate

Species Most Affected

Dog 98
Cat 17

Breeds Most Affected

Domestic Shorthair 14
Shih Tzu 8
Terrier - Yorkshire 7
Chihuahua 6
Dog (unknown) 5
Schnauzer (unspecified) 5
Poodle - Miniature 4
Pinscher - Miniature 4
Pug 4
Dachshund - Miniature 3

Associated Drugs

Trilostane 82
Insulin 35
Oclacitinib Maleate 9
Frunevetmab 5
Prednisone 4
Enrofloxacin 4
Insulin Injectable Vial 4
Capromorelin 4
Capromorelin Tartrate 4
Nph Insulin 3
Tramadol 3
Cyclosporine 3
Fluralaner Chew Tablets 3
Porcine Insulin Zinc Suspension 3
Spinosad 2
Insulin (Unknown) 2
Desoxycorticosterone Pivalate 2
Amlodipine 2
Hydroxyzine 2
Anti-Il31 Mab Mcs Lot #1283563 2

Uncontrolled diabetes Reaction Insights

115 reports name Uncontrolled diabetes; 24 recorded a death outcome (20.9% of reported events, not a population-level mortality rate). VeDDRA code: 388.

By species: Dog (98 reports), Cat (17 reports). By breed: Domestic Shorthair (14), Shih Tzu (8), Terrier - Yorkshire (7).

Most co-reported drugs: Trilostane (82 reports), Insulin (35 reports), Oclacitinib Maleate (9 reports), Frunevetmab (5 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.