Reaction profile

The FDA adverse-event record for spasm

403 FDA adverse-event reports reference spasm (VeDDRA 681). See the species, breeds, and drugs most associated with it below.

403
reports citing this reaction
20.8%
death-coded share
Dog
most-affected species
Sarolaner
most-associated drug
Verify with FDA CVM →
403
Total Reports
84
Deaths
20.8%
Death Rate

Species Most Affected

Dog 297
Cat 68
Horse 23
Cattle 3
Human 3
Rabbit 3
Other 2
Mouse 1
Bison 1
Sheep 1

Breeds Most Affected

Crossbred Canine/dog 38
Domestic (unspecified) 22
Retriever - Labrador 22
Dog (unknown) 18
Chihuahua 17
Terrier - Yorkshire 16
Shih Tzu 14
Cat (unknown) 14
Retriever - Golden 14
Domestic Shorthair 14

Associated Drugs

Sarolaner 25
Afoxolaner 24
Spinosad 23
Milbemycin Oxime + Spinosad 23
Ketamine Hydrochloride 21
Selamectin 18
Propofol 17
Pyrantel Pamoate;Sarolaner 17
Maropitant Citrate 16
Bedinvetmab 15
Meloxicam 13
Gabapentin 13
Fluralaner Chew Tablets 12
Ivermectin + Pyrantel As Pamoate Salt 10
Carprofen 9
Enrofloxacin 8
Ivermectin, Pyrantel 7
Tiletamine, Zolazepam 7
Prednisone 7
Fipronil 9.8%/S-Methoprene 8.8%/Cyphenothrin 5.2% Squeeze-On 7

Spasm Reaction Insights

403 reports name Spasm; 84 recorded a death outcome (20.8% of reported events, not a population-level mortality rate). VeDDRA code: 681.

By species: Dog (297 reports), Cat (68 reports), Horse (23 reports). By breed: Crossbred Canine/dog (38), Domestic (unspecified) (22), Retriever - Labrador (22).

Most co-reported drugs: Sarolaner (25 reports), Afoxolaner (24 reports), Spinosad (23 reports), Milbemycin Oxime + Spinosad (23 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.