Reaction profile

The FDA adverse-event record for swollen mouth

367 FDA reports name swollen mouth, a high-volume reaction in the CVM extract (VeDDRA 1819). Plate stamps and neighbourhood peers follow.

#785 of 2,481
by report volume (all reactions)
367
reports citing this reaction
0.3%
death-coded share
Horse
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Swollen mouth has 367 reports now versus 365 in that prior snapshot: 2 more (0.5%).

Report change
+2
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Swollen mouth changes

FDA AER · VeDDRA plate

Code 1819 VOL-LOW

VOL-LOW · DEATH-RARE · MID-PACK · PHOTO-FINISH · SPECIES-HORSE · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 367 reports
  • DEATH-RARE 0.3%
  • MID-PACK #785/2481
  • PHOTO-FINISH Administration device…
  • SPECIES-HORSE Horse · 297
  • DRUG-LEAD Ivermectin(1.55%)… · 211
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Administration device NOS, malfunction (±0 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Swollen mouth

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Administration device… · near367Application site rash · near367Hallucination · near367Nasal bleeding · near367Swollen mouth · this reaction367Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Swollen mouth

Swollen mouth: low death-coded share in the FDA AER plate

Signature read: Swollen mouth's 0.3% death-coded share is among the lowest in the openFDA reaction corpus. Report volume is upper-third scale: 367 named reports in the openFDA extract. Death-coded share is lower-third: 1 of 367 reports (0.3% of named reports). Nearest volume peer: Administration device NOS, malfunction (±0 reports). Lead species Horse (297). Lead co-reported drug Ivermectin(1.55%)/Praziquantel(7.75%) Paste (211).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Ivermectin(1.55%)/Praziquantel(7.75%) Paste appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Horse 297
Dog 42
Cat 14
Human 7
Donkey 3
Cattle 2
Sheep 1
Unknown 1

Breeds Most Affected

Horse (unknown) 66
Quarter Horse 57
Thoroughbred 56
Unknown 16
Arab 16
Paint 15
Horse (other) 14
Tennessee Walking Horse 9
Domestic Shorthair 7
Warmblood - Dutch 6

Associated Drugs

Ivermectin(1.55%)/Praziquantel(7.75%) Paste 211
Ivermectin + Praziquantel 76
Milbemycin Oxime + Spinosad 11
Ivermectin/Praziquantel Paste 10
Moxidectin 8
Ivermectin + Pyrantel As Pamoate Salt 5
Propofol 4
Buprenorphine 4
Carprofen 4
Firocoxib 227 Mg Chewable 4
Afoxolaner 4
Diphenhydramine Hcl 3
Firocoxib 3
Oclacitinib Maleate 3
Sevoflurane 2
Imidacloprid + Moxidectin 2
Shampoo 2
Selamectin 2
Firocoxib 57 Mg Chewable 2
Cyclosporine A 2

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Swollen mouth, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (367 here).

Similar death-coded share

Nearest other reactions by death-coded share (0.3% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Swollen mouth (#785 of 2,481 by report volume); death-coded 0.3%. PlainBreed reaction plate · death-coded share stamp 0.3% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →