Reaction profile

The FDA adverse-event record for granules/powder, abnormal

389 FDA reports name granules/powder, abnormal, a high-volume reaction in the CVM extract (VeDDRA 99012). Plate stamps and neighbourhood peers follow.

#742 of 2,481
by report volume (all reactions)
389
reports citing this reaction
0.3%
death-coded share
Unknown
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Granules/Powder, Abnormal has 389 reports now versus 389 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Granules/Powder, Abnormal changes

FDA AER · VeDDRA plate

Code 99012 VOL-LOW

VOL-LOW · DEATH-RARE · MID-PACK · PHOTO-FINISH · SPECIES-UNKNOWN · DRUG-LEAD · DESK-MID · BOOK-FULL

  • VOL-LOW 389 reports
  • DEATH-RARE 0.3%
  • MID-PACK #742/2481
  • PHOTO-FINISH Application site sore
  • SPECIES-UNKNOWN Unknown · 384
  • DRUG-LEAD Amoxicillin Trihy… · 136
  • DESK-MID 4 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Application site sore (±0 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Granules/Powder, Abnormal

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Basophilia · near391Fasciculation · near390Application site sore · near389Granules/Powder, Abno… · thi…389PR-EAR(S), LESION(S) · near389Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Granules/Powder, Abnormal

Granules/Powder, Abnormal: low death-coded share in the FDA AER plate

Signature read: Granules/Powder, Abnormal's 0.3% death-coded share is among the lowest in the openFDA reaction corpus. Report volume is upper-third scale: 389 named reports in the openFDA extract. Death-coded share is lower-third: 1 of 389 reports (0.3% of named reports). Nearest volume peer: Application site sore (±0 reports). Lead species Unknown (384). Lead co-reported drug Amoxicillin Trihydrate;Clavulanate Potassium ( K-Clavulanate) (136).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Amoxicillin Trihydrate;Clavulanate Potassium ( K-Clavulanate) appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Unknown 384
Human 2
Pig 1
Dog 1
Cattle 1

Breeds Most Affected

Unknown 386
Pig (unknown) 1
Crossbred Canine/dog 1
Cattle (other) 1

Associated Drugs

Amoxicillin Trihydrate;Clavulanate Potassium ( K-Clavulanate) 136
Amoxicillin, Clavulanate 58
Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate) 39
Cefovecin 29
Ceftiofur Sodium 17
Fenbendazole 9
Cefovecin Sodium 9
Tylosin Tartrate 7
Melarsomine Dihydrocloride Injectable 25Mg/Ml 6
Melarsomine Dihydrochloride Injection 6
Amoxicillin As Trihydrate; Clavulanate Potassium ( K-Clavulanate) 6
Chlortetracycline 4
Tylosin 4
Nitarsone 4
Amoxicillin (As Trihydrate); Clavulanate Potassium ( K-Clavulanate) 4
Moxidectin 4
Pyrantel Tartrate 3
Oxytetracycline Hydrochloride 3
Fenbendazol Granules 3
Selamectin 2

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Granules/Powder, Abnormal, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (389 here).

Similar death-coded share

Nearest other reactions by death-coded share (0.3% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Granules/Powder, Abnormal (#742 of 2,481 by report volume); death-coded 0.3%. PlainBreed reaction plate · death-coded share stamp 0.3% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →