Reaction profile

The FDA adverse-event record for swollen joint

131 FDA adverse-event reports reference swollen joint (VeDDRA 1816). See the species, breeds, and drugs most associated with it below.

131
reports citing this reaction
17.6%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
131
Total Reports
23
Deaths
17.6%
Death Rate

Species Most Affected

Dog 86
Cattle 19
Cat 14
Horse 8
Human 3
Chicken 1

Breeds Most Affected

Retriever - Labrador 15
Domestic Shorthair 10
Shepherd Dog - German 8
Cattle (other) 7
Retriever - Golden 7
Holstein-Friesian also known as Holstein 5
Unknown 4
Shar Pei 4
Mixed (Cattle) 4
Crossbred Canine/dog 4

Associated Drugs

Bedinvetmab 38
Carprofen 25
Oclacitinib Maleate 18
Gabapentin 14
Frunevetmab 12
Prednisone 8
Tulathromycin 7
Deracoxib 6
Maropitant Citrate 6
Tramadol 5
Doxycycline 5
Enrofloxacin 5
Lotilaner 5
Ceftiofur Crystalline Free Acid 4
Anti-Il31 Mab Mcs Lot #1283563 4
Pyrantel Pamoate;Sarolaner 4
Milbemycin Oxime + Praziquantel 4
Famotidine 4
Galliprant 4
Bovine Respiratory Syncytial Virus, 597-10 10Th Psg Strain 375; Bovine Viral Dia 3

Swollen joint Reaction Insights

131 reports name Swollen joint; 23 recorded a death outcome (17.6% of reported events, not a population-level mortality rate). VeDDRA code: 1816.

By species: Dog (86 reports), Cattle (19 reports), Cat (14 reports). By breed: Retriever - Labrador (15), Domestic Shorthair (10), Shepherd Dog - German (8).

Most co-reported drugs: Bedinvetmab (38 reports), Carprofen (25 reports), Oclacitinib Maleate (18 reports), Gabapentin (14 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.