Reaction profile

The FDA adverse-event record for star-gazing

897 FDA adverse-event reports reference star-gazing (VeDDRA 2246). See the species, breeds, and drugs most associated with it below.

897
reports citing this reaction
4.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
897
Total Reports
39
Deaths
4.3%
Death Rate

Species Most Affected

Dog 844
Cat 48
Horse 3
Cattle 2

Breeds Most Affected

Chihuahua 76
Maltese 73
Terrier - Yorkshire 70
Crossbred Canine/dog 52
Retriever - Labrador 39
Retriever - Golden 35
Shih Tzu 33
Boxer (German Boxer) 25
Domestic Shorthair 25
Pug 23

Associated Drugs

Milbemycin Oxime + Spinosad 640
Spinosad 73
Afoxolaner 48
Ivermectin + Pyrantel As Pamoate Salt 26
Fluralaner Chew Tablets 25
Trilostane 22
Sarolaner 19
Oclacitinib Maleate 18
Buprenorphine 18
Carprofen 16
Moxidectin 14
Ivermectin 13
Maropitant Citrate 12
Cefovecin 10
Bordetella Vaccine 9
Selamectin 9
Milbemycin Oxime, Lufenuron 8
Milbemycin Oxime 8
Milbemycin Oxime + Praziquantel 8
Vaccines (Unknown) 7

Star-gazing Reaction Insights

897 reports name Star-gazing; 39 recorded a death outcome (4.3% of reported events, not a population-level mortality rate). VeDDRA code: 2246.

By species: Dog (844 reports), Cat (48 reports), Horse (3 reports). By breed: Chihuahua (76), Maltese (73), Terrier - Yorkshire (70).

Most co-reported drugs: Milbemycin Oxime + Spinosad (640 reports), Spinosad (73 reports), Afoxolaner (48 reports), Ivermectin + Pyrantel As Pamoate Salt (26 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.