Reaction profile

The FDA adverse-event record for application site burn

874 FDA adverse-event reports reference application site burn (VeDDRA 2063). See the species, breeds, and drugs most associated with it below.

874
reports citing this reaction
1.1%
death-coded share
Cat
most-affected species
Selamectin
most-associated drug
Verify with FDA CVM →
874
Total Reports
10
Deaths
1.1%
Death Rate

Species Most Affected

Cat 706
Dog 104
Horse 42
Human 11
Cattle 7
Unknown 2
Rabbit 1
Goat 1

Breeds Most Affected

Domestic Shorthair 412
Cat (other) 80
Domestic Mediumhair 45
Domestic Longhair 44
Cat (unknown) 24
Siamese 20
Maine Coon 15
Unknown 14
Horse (unknown) 12
Retriever - Labrador 11

Associated Drugs

Selamectin 255
Selamectin;Sarolaner 245
Fluralaner Spot-On Solution 98
Imidacloprid + Moxidectin 67
Fluralaner/Moxidectin Spot-On 35
Emodepside + Praziquantel 30
Ivermectin(1.55%)/Praziquantel(7.75%) Paste 28
Ivermectin + Pyrantel As Pamoate Salt 13
Cefovecin 12
Flumethrin-Imidacloprid 11
Buprenorphine 11
Eprinomectin + Esafoxolaner + Praziquantel 11
Ivermectin + Praziquantel 10
Enrofloxacin 8
Fipronil 10%/S Methoprene 9% Spot On 7
Prednisone 7
Fipronil 9.8%/S-Methoprene 8.8%/Cyphenothrin 5.2% Squeeze-On 7
Methylprednisolone Acetate 7
Imidacloprid, Flumethrin 7
Fipronil 9.8%/S-Methoprene 8.8%/ Amitraz 22.1% Spot-On 6

Application site burn Reaction Insights

874 reports name Application site burn; 10 recorded a death outcome (1.1% of reported events, not a population-level mortality rate). VeDDRA code: 2063.

By species: Cat (706 reports), Dog (104 reports), Horse (42 reports). By breed: Domestic Shorthair (412), Cat (other) (80), Domestic Mediumhair (45).

Most co-reported drugs: Selamectin (255 reports), Selamectin;Sarolaner (245 reports), Fluralaner Spot-On Solution (98 reports), Imidacloprid + Moxidectin (67 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.