Reaction profile

The FDA adverse-event record for small intestinal bacterial overgrowth

54 FDA adverse-event reports reference small intestinal bacterial overgrowth (VeDDRA 2565). See the species, breeds, and drugs most associated with it below.

54
reports citing this reaction
7.4%
death-coded share
Dog
most-affected species
Ivermectin + Pyrantel As Pamoate Salt
most-associated drug
Verify with FDA CVM →
54
Total Reports
4
Deaths
7.4%
Death Rate

Species Most Affected

Dog 46
Cat 5
Pig 1
Ferret 1
Horse 1

Breeds Most Affected

Crossbred Canine/dog 7
Retriever - Labrador 5
Retriever - Golden 3
Terrier - Yorkshire 2
Boxer (German Boxer) 2
Havanese 2
Shepherd Dog - Australian 2
Domestic Shorthair 2
Maltese 2
Mastiff 2

Associated Drugs

Ivermectin + Pyrantel As Pamoate Salt 11
Milbemycin Oxime + Praziquantel 9
Afoxolaner 7
Meloxicam 5
Metronidazole 4
Lotilaner 4
Trilostane 3
Fluralaner 13.64% 12-Week Chew 3
Polysulfated Glycosaminoglycan 3
Maropitant Citrate 3
Enrofloxacin 2
Gabapentin 2
Rabies Virus,Pv-11,Killed 2
Oclacitinib Maleate 2
Carprofen 2
Milbemycin Oxime 2
Famotidine 2
Citric Acid + Edetate Trisodium + Glycerin + Methyl Salicylate + Sodium Laureth-3 Sulfate 1
Febantel + Praziquantel + Pyrantel Pamoate 1
Iron 200 Supplement 1

Small intestinal bacterial overgrowth Reaction Insights

54 reports name Small intestinal bacterial overgrowth; 4 recorded a death outcome (7.4% of reported events, not a population-level mortality rate). VeDDRA code: 2565.

By species: Dog (46 reports), Cat (5 reports), Pig (1 reports). By breed: Crossbred Canine/dog (7), Retriever - Labrador (5), Retriever - Golden (3).

Most co-reported drugs: Ivermectin + Pyrantel As Pamoate Salt (11 reports), Milbemycin Oxime + Praziquantel (9 reports), Afoxolaner (7 reports), Meloxicam (5 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.