Reaction profile

The FDA adverse-event record for small intestinal bacterial overgrowth

57 FDA reports name small intestinal bacterial overgrowth, a lower-volume reaction in the CVM extract (VeDDRA 2565). Plate stamps and neighbourhood peers follow.

#1679 of 2,481
by report volume (all reactions)
57
reports citing this reaction
7.0%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Small intestinal bacterial overgrowth has 57 reports now versus 56 in that prior snapshot: 1 more (1.8%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Small intestinal bacterial overgrowth changes

FDA AER · VeDDRA plate

Code 2565 VOL-LOW

VOL-LOW · DEATH-PAR · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 57 reports
  • DEATH-PAR 7.0%
  • MID-PACK #1679/2481
  • PHOTO-FINISH Atrial fibrillation
  • SPECIES-DOG Dog · 49
  • DRUG-LEAD Ivermectin + Pyra… · 12
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Atrial fibrillation (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Small intestinal bacterial overgrowth

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Atrial fibrillation · near57Epistaxis (unilateral) · near57Eyelid lump · near57Lack of efficacy (bac… · near57Small intestinal bact… · thi…57Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Small intestinal bacterial overgrowth

Small intestinal bacterial overgrowth: low death-coded share in the FDA AER plate

Signature read: 4 death-coded reports is a thin tail count for Small intestinal bacterial overgrowth in the CVM extract. Report volume is lower-third scale: 57 named reports in the openFDA extract. Death-coded share is lower-third: 4 of 57 reports (7.0% of named reports). Nearest volume peer: Atrial fibrillation (±0 reports). Lead species Dog (49). Lead co-reported drug Ivermectin + Pyrantel As Pamoate Salt (12).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Ivermectin + Pyrantel As Pamoate Salt appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 49
Cat 5
Pig 1
Ferret 1
Horse 1

Breeds Most Affected

Crossbred Canine/dog 8
Retriever - Labrador 7
Retriever - Golden 3
Terrier - Yorkshire 2
Boxer (German Boxer) 2
Havanese 2
Shepherd Dog - Australian 2
Domestic Shorthair 2
Maltese 2
Mastiff 2

Associated Drugs

Ivermectin + Pyrantel As Pamoate Salt 12
Milbemycin Oxime + Praziquantel 9
Afoxolaner 7
Meloxicam 5
Metronidazole 4
Lotilaner 4
Maropitant Citrate 4
Trilostane 3
Fluralaner 13.64% 12-Week Chew 3
Polysulfated Glycosaminoglycan 3
Tylosin 3
Enrofloxacin 2
Gabapentin 2
Rabies Virus,Pv-11,Killed 2
Oclacitinib Maleate 2
Milbemycin Oxime 2
Carprofen 2
Famotidine 2
Citric Acid + Edetate Trisodium + Glycerin + Methyl Salicylate + Sodium Laureth-3 Sulfate 1
Febantel + Praziquantel + Pyrantel Pamoate 1

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Small intestinal bacterial overgrowth, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (7.0% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Small intestinal bacterial overgrowth (#1679 of 2,481 by report volume); death-coded 7.0%. PlainBreed reaction plate · death-coded report count stamp 4 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →