Reaction profile

The FDA adverse-event record for abnormal adrenocorticotropic hormone (acth) stimulation test

920 FDA reports name abnormal adrenocorticotropic hormone (acth) stimulation test, a high-volume reaction in the CVM extract (VeDDRA 2663). Plate stamps and neighbourhood peers follow.

#420 of 2,481
by report volume (all reactions)
920
reports citing this reaction
7.1%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Abnormal adrenocorticotropic hormone (ACTH) stimulation test has 920 reports now versus 907 in that prior snapshot: 13 more (1.4%).

Report change
+13
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Abnormal adrenocorticotropic hormone (ACTH) stimulation test changes

FDA AER · VeDDRA plate

Code 2663 VOL-MID

VOL-MID · DEATH-PAR · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 920 reports
  • DEATH-PAR 7.1%
  • UPPER-Q #420/2481
  • PHOTO-FINISH Arrhythmia
  • SPECIES-DOG Dog · 916
  • DRUG-LEAD Trilostane · 1,332
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Arrhythmia (±2 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Abnormal adrenocorticotropic hormone stimulati…

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Hyperalbuminaemia · near927Reduced responses · near924Knuckling · near923Abnormal adrenocortic… · thi…920Arrhythmia · near918Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Abnormal adrenocorticotropic hormone (ACTH) stimulation test

Abnormal adrenocorticotropic hormone (ACTH) stimulation test: low death-coded share in the FDA AER plate

Signature read: 920 reports place Abnormal adrenocorticotropic hormone (ACTH) stimulation test in the upper third of FDA AER volume (#420 of 2,481). Report volume is upper-third scale: 920 named reports in the openFDA extract. Death-coded share is lower-third: 65 of 920 reports (7.1% of named reports). Nearest volume peer: Arrhythmia (±2 reports). Lead species Dog (916). Lead co-reported drug Trilostane (1,332).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Trilostane appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 916
Horse 2
Cat 2

Breeds Most Affected

Retriever - Labrador 92
Terrier - Boston 51
Crossbred Canine/dog 46
Maltese 43
Boxer (German Boxer) 41
Chihuahua 38
American Pit Bull Terrier 34
Shih Tzu 32
Spaniel (unspecified) 32
Beagle 31

Associated Drugs

Trilostane 1,332
Carprofen 31
Gabapentin 23
Pimobendan 23
Levothyroxine 22
Insulin Injectable Vial 17
Grapiprant 17
Insulin 15
Amlodipine 15
Oclacitinib Maleate 15
Enalapril 14
Benazepril 11
Ursodiol 11
Bedinvetmab 11
Lokivetmab 10
Prednisone 9
Same And Silybin 9
Milbemycin Oxime + Spinosad 8
Tramadol 7
Afoxolaner 7

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Abnormal adrenocorticotropic hormone (ACTH) stimulation test, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (920 here).

Similar death-coded share

Nearest other reactions by death-coded share (7.1% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Abnormal adrenocorticotropic hormone (ACTH) stimulation test (#420 of 2,481 by report volume); death-coded 7.1%. PlainBreed reaction plate · report volume stamp 920 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →