Immediate pain upon injection
VeDDRA Code: 2410
539 adverse event reports referencing this reaction
Species Most Affected
Breeds Most Affected
Associated Drugs
Data Summary
| Metric | Value |
|---|---|
| Total reports referencing reaction | 539 |
| Reports with fatal outcome | 21 |
| Case-fatality rate (reported events) | 390.0% |
| Species observed | 9 |
| Breeds observed | 20 |
| Drugs associated with reaction | 20 |
Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 2410.
Immediate pain upon injection Reaction Insights
The FDA Center for Veterinary Medicine database currently lists 539 adverse event reports that reference Immediate pain upon injection as a reaction term, including 21 reports with a death outcome — a 390.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 2410, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.
Immediate pain upon injection appears most frequently in reports for Dog (434 reports), Cat (75 reports), Human (9 reports) — with Dog dominating at 434 entries. Within those species, the breeds most often named alongside this reaction are Dog (unknown) (85), Retriever - Labrador (36), Domestic Shorthair (33). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.
The drugs most commonly co-reported with Immediate pain upon injection are Desoxycorticosterone Pivalate (247 reports), Prednisone (135 reports), Maropitant Citrate (50 reports), Desoxycortone Pivalate (46 reports), with Desoxycorticosterone Pivalate appearing alongside this reaction in 247 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.
Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates
Read our methodology — how this data is sourced, computed, and verified.