Reaction profile

The FDA adverse-event record for immediate pain upon injection

539 FDA adverse-event reports reference immediate pain upon injection (VeDDRA 2410). See the species, breeds, and drugs most associated with it below.

539
reports citing this reaction
3.9%
death-coded share
Dog
most-affected species
Desoxycorticosterone Pivalate
most-associated drug
Verify with FDA CVM →
539
Total Reports
21
Deaths
3.9%
Death Rate

Species Most Affected

Dog 434
Cat 75
Human 9
Horse 9
Cattle 6
Goat 2
Pig 2
Other 1
Unknown 1

Breeds Most Affected

Dog (unknown) 85
Retriever - Labrador 36
Domestic Shorthair 33
Cat (other) 28
Crossbred Canine/dog 23
Poodle - Standard 22
Chihuahua 19
Retriever - Golden 19
Beagle 18
Unknown 16

Associated Drugs

Desoxycorticosterone Pivalate 247
Prednisone 135
Maropitant Citrate 50
Desoxycortone Pivalate 46
Frunevetmab 44
Docp 41
Bedinvetmab 40
Cefovecin 24
Melarsomine Dihydrochloride 21
Desoxycorticosterone Pivalate (Docp) 21
Gabapentin 17
Medetomidine Hydrochloride, Vatinoxan Hydrochloride 12
Insulin Injectable Vial 11
Oclacitinib Maleate 10
Polysulfated Glycosaminoglycan 10
Butorphanol 10
Anti-Il31 Mab Mcs Lot #1283563 9
Moxidectin 8
Prednisolone 7
Famotidine 7

Immediate pain upon injection Reaction Insights

539 reports name Immediate pain upon injection; 21 recorded a death outcome (3.9% of reported events, not a population-level mortality rate). VeDDRA code: 2410.

By species: Dog (434 reports), Cat (75 reports), Human (9 reports). By breed: Dog (unknown) (85), Retriever - Labrador (36), Domestic Shorthair (33).

Most co-reported drugs: Desoxycorticosterone Pivalate (247 reports), Prednisone (135 reports), Maropitant Citrate (50 reports), Desoxycortone Pivalate (46 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.