Reaction profile

The FDA adverse-event record for rapid pulse rate

68 FDA adverse-event reports reference rapid pulse rate (VeDDRA 1719). See the species, breeds, and drugs most associated with it below.

68
reports citing this reaction
26.5%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
68
Total Reports
18
Deaths
26.5%
Death Rate

Species Most Affected

Dog 54
Cat 8
Human 3
Horse 3

Breeds Most Affected

Domestic Shorthair 6
Shih Tzu 5
Unknown 4
Shepherd Dog - German 4
Collie - Border 3
Retriever - Golden 3
Terrier - Yorkshire 3
Spitz - German Pomeranian 3
Crossbred Canine/dog 3
Boxer (German Boxer) 2

Associated Drugs

Milbemycin Oxime + Spinosad 15
Bedinvetmab 6
Moxidectin 5
Milbemycin Oxime + Praziquantel 5
Gabapentin 5
Maropitant Citrate 4
Lotilaner 4
Tramadol 4
Carprofen 3
Vaccines (Unknown) 3
Rabies Vaccine, Killed Virus 3
Oclacitinib Maleate 3
Diphenhydramine 3
Pyrantel Pamoate;Sarolaner 3
Polysulfated Glycosaminoglycan 3
Prednisone 2
Spinosad 2
Sarolaner 2
Hydromorphone 2
Buprenorphine 2

Rapid pulse rate Reaction Insights

68 reports name Rapid pulse rate; 18 recorded a death outcome (26.5% of reported events, not a population-level mortality rate). VeDDRA code: 1719.

By species: Dog (54 reports), Cat (8 reports), Human (3 reports). By breed: Domestic Shorthair (6), Shih Tzu (5), Unknown (4).

Most co-reported drugs: Milbemycin Oxime + Spinosad (15 reports), Bedinvetmab (6 reports), Moxidectin (5 reports), Milbemycin Oxime + Praziquantel (5 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.