Reaction profile

The FDA adverse-event record for otitis nos

688 FDA adverse-event reports reference otitis nos (VeDDRA 1984). See the species, breeds, and drugs most associated with it below.

688
reports citing this reaction
6.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
688
Total Reports
43
Deaths
6.3%
Death Rate

Species Most Affected

Dog 610
Cat 77
Pig 1

Breeds Most Affected

Retriever - Labrador 96
Domestic Shorthair 44
Shih Tzu 41
Retriever - Golden 40
Crossbred Canine/dog 25
Beagle 25
Shepherd Dog - German 21
Dog (unknown) 18
Bulldog 17
Boxer (German Boxer) 17

Associated Drugs

Milbemycin Oxime + Spinosad 172
Oclacitinib Maleate 137
Anti-Il31 Mab Mcs Lot #1283563 41
Bedinvetmab 33
Afoxolaner 32
Spinosad 30
Carprofen 29
Frunevetmab 28
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 26
Trilostane 25
Prednisone 25
Milbemycin Oxime + Praziquantel 25
Gabapentin 23
Maropitant Citrate 20
Fluralaner Chew Tablets 20
Fluralaner 13.64% 12-Week Chew 20
Cefpodoxime Proxetil 19
Enrofloxacin 18
Moxidectin 17
Cyclosporine 17

Otitis NOS Reaction Insights

688 reports name Otitis NOS; 43 recorded a death outcome (6.3% of reported events, not a population-level mortality rate). VeDDRA code: 1984.

By species: Dog (610 reports), Cat (77 reports), Pig (1 reports). By breed: Retriever - Labrador (96), Domestic Shorthair (44), Shih Tzu (41).

Most co-reported drugs: Milbemycin Oxime + Spinosad (172 reports), Oclacitinib Maleate (137 reports), Anti-Il31 Mab Mcs Lot #1283563 (41 reports), Bedinvetmab (33 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.