Reaction profile

The FDA adverse-event record for otitis nos

726 FDA reports name otitis nos, a high-volume reaction in the CVM extract (VeDDRA 1984). Plate stamps and neighbourhood peers follow.

#495 of 2,481
by report volume (all reactions)
726
reports citing this reaction
6.2%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Otitis NOS has 726 reports now versus 708 in that prior snapshot: 18 more (2.5%).

Report change
+18
Death-coded reports
+0
Death-coded share
−0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Otitis NOS changes

FDA AER · VeDDRA plate

Code 1984 VOL-MID

VOL-MID · DEATH-PAR · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 726 reports
  • DEATH-PAR 6.2%
  • UPPER-Q #495/2481
  • PHOTO-FINISH Anisocoria
  • SPECIES-DOG Dog · 641
  • DRUG-LEAD Milbemycin Oxime… · 172
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Anisocoria (±0 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Otitis NOS

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Anisocoria · near726Intestinal perforation · near726Muscle shaking · near726Otitis NOS · this reaction726Balance impaired · near725Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Otitis NOS

Otitis NOS: low death-coded share in the FDA AER plate

Signature read: 726 reports place Otitis NOS in the upper third of FDA AER volume (#495 of 2,481). Report volume is upper-third scale: 726 named reports in the openFDA extract. Death-coded share is lower-third: 45 of 726 reports (6.2% of named reports). Nearest volume peer: Anisocoria (±0 reports). Lead species Dog (641). Lead co-reported drug Milbemycin Oxime + Spinosad (172).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 641
Cat 84
Pig 1

Breeds Most Affected

Retriever - Labrador 101
Domestic Shorthair 50
Retriever - Golden 43
Shih Tzu 41
Crossbred Canine/dog 28
Beagle 25
Shepherd Dog - German 25
Dog (unknown) 18
Bulldog 17
Boxer (German Boxer) 17

Associated Drugs

Milbemycin Oxime + Spinosad 172
Oclacitinib Maleate 143
Anti-Il31 Mab Mcs Lot #1283563 43
Bedinvetmab 38
Afoxolaner 33
Prednisone 31
Carprofen 31
Frunevetmab 31
Spinosad 30
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 29
Milbemycin Oxime + Praziquantel 27
Trilostane 26
Maropitant Citrate 24
Gabapentin 24
Fluralaner 13.64% 12-Week Chew 21
Fluralaner Chew Tablets 20
Moxidectin 19
Cefpodoxime Proxetil 19
Enrofloxacin 18
Cyclosporine 17

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Otitis NOS, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (726 here).

Similar death-coded share

Nearest other reactions by death-coded share (6.2% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Otitis NOS (#495 of 2,481 by report volume); death-coded 6.2%. PlainBreed reaction plate · report volume stamp 726 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →