Reaction profile

The FDA adverse-event record for hissing

66 FDA adverse-event reports reference hissing (VeDDRA 2754). See the species, breeds, and drugs most associated with it below.

66
reports citing this reaction
7.6%
death-coded share
Cat
most-affected species
Selamectin;Sarolaner
most-associated drug
Verify with FDA CVM →
66
Total Reports
5
Deaths
7.6%
Death Rate

Species Most Affected

Cat 65
Dog 1

Breeds Most Affected

Domestic Shorthair 32
Domestic Longhair 10
Domestic Mediumhair 7
Cat (unknown) 5
Maine Coon 3
Cat (other) 2
Siamese 2
Terrier - Yorkshire 1
American Curl Shorthair 1
Manx 1

Associated Drugs

Selamectin;Sarolaner 9
Frunevetmab 9
Buprenorphine 8
Eprinomectin + Esafoxolaner + Praziquantel 7
Fluralaner Spot-On Solution 6
Nitenpyram 5
Maropitant Citrate 5
Prednisolone 5
Gabapentin 5
Enrofloxacin 5
Selamectin 3
Isoflurane 3
Lotilaner 3
Meloxicam 3
Emodepside + Praziquantel 2
Cisapride 2
Fluoxetine 2
Cefovecin Sodium 2
Fluid Therapy (Unknown) 2
Bexagliflozin 2

Hissing Reaction Insights

66 reports name Hissing; 5 recorded a death outcome (7.6% of reported events, not a population-level mortality rate). VeDDRA code: 2754.

By species: Cat (65 reports), Dog (1 reports). By breed: Domestic Shorthair (32), Domestic Longhair (10), Domestic Mediumhair (7).

Most co-reported drugs: Selamectin;Sarolaner (9 reports), Frunevetmab (9 reports), Buprenorphine (8 reports), Eprinomectin + Esafoxolaner + Praziquantel (7 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.