Reaction profile

The FDA adverse-event record for hissing

Name: Hissing - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

81 FDA adverse-event reports reference hissing (VeDDRA 2754). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1493 of 2,481
by report volume (all reactions): 81
reports citing this reaction: 6.2%
death-coded share: Cat
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hissing has 81 reports now versus 75 in that prior snapshot: 6 more (8.0%).

Report change: +6
Death-coded reports: +0
Death-coded share: −0.5 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hissing changes

FDA AER · VeDDRA plate

Code 2754 VOL-LOW

VOL-LOW · DEATH-PAR · MID-PACK · PHOTO-FINISH · SPECIES-CAT · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-LOW 81 reports
DEATH-PAR 6.2%
MID-PACK #1493/2481
PHOTO-FINISH INEFFECTIVE, NEOPLASIA
SPECIES-CAT Cat · 80
DRUG-LEAD Selamectin;Sarola… · 10
DESK-WIDE 13 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: INEFFECTIVE, NEOPLASIA (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Hissing

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

FDA AER report volume · neighbourhood around Hissing

Hissing: low death-coded share in the FDA AER plate

Signature read: 5 death-coded reports is a thin tail count for Hissing in the CVM extract. Report volume sits in the middle third of the reaction corpus. Death-coded share is lower-third: 5 of 81 reports (6.2% of named reports). Nearest volume peer: INEFFECTIVE, NEOPLASIA (±0 reports). Lead species Cat (80). Lead co-reported drug Selamectin;Sarolaner (10).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Selamectin;Sarolaner appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Cat 80

Dog 1

Breeds Most Affected

Domestic Shorthair 38

Domestic Mediumhair 13

Domestic Longhair 11

Cat (unknown) 5

Maine Coon 3

Cat (other) 3

Siamese 2

Terrier - Yorkshire 1

American Curl Shorthair 1

Manx 1

Associated Drugs

Selamectin;Sarolaner 10

Frunevetmab 10

Gabapentin 9

Buprenorphine 9

Fluralaner Spot-On Solution 8

Nitenpyram 7

Eprinomectin + Esafoxolaner + Praziquantel 7

Maropitant Citrate 5

Prednisolone 5

Isoflurane 5

Enrofloxacin 5

Cefovecin Sodium 4

Robenacoxib 4

Cefovecin 4

Fvrcp Vaccine 4

Emodepside + Praziquantel 3

Selamectin 3

Bexagliflozin 3

Lotilaner 3

Meloxicam 3

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Hissing, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (81 here).

INEFFECTIVE, NEOPLASIA 81 Potency, High 81 Wrong strength dispensed 81 Blepharitis 82

Similar death-coded share

Nearest other reactions by death-coded share (6.2% here), distinct from the volume row.

Deafness NOS 6.2% INEFFECTIVE, WORMS NOS 6.2% Hypersensitivity NOS 6.2% Otitis NOS 6.2%

What to do with this reaction

Compare Hissing's report profile against similar reactions nationwide. See similar reactions
Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hissing (#1493 of 2,481 by report volume); death-coded 6.2%. PlainBreed reaction plate · death-coded report count stamp 5 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →