Reaction profile

The FDA adverse-event record for neurogenic keratoconjunctivitis sicca (kcs)

129 FDA adverse-event reports reference neurogenic keratoconjunctivitis sicca (kcs) (VeDDRA 2866). See the species, breeds, and drugs most associated with it below.

129
reports citing this reaction
4.7%
death-coded share
Dog
most-affected species
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride
most-associated drug
Verify with FDA CVM →
129
Total Reports
6
Deaths
4.7%
Death Rate

Species Most Affected

Dog 129

Breeds Most Affected

Shih Tzu 16
Chihuahua 10
Terrier - Rat 9
Dachshund (unspecified) 9
Dog (unknown) 6
Maltese 6
Crossbred Canine/dog 5
Terrier (unspecified) 5
Terrier - Yorkshire 5
Retriever - Labrador 5

Associated Drugs

Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 92
Maropitant Citrate 27
Prednisone 21
Enrofloxacin 16
Cyclosporine (Ophthalmic) 16
Florfenicol, Terbinafine, Betamethasone Acetate 15
Pilocarpine 13
Bordetella Vaccine 11
Gabapentin 11
Ear Cleaner (Unknown) 10
Pilocarpine Ophthalmic 10
Ofloxacin 9
Cefovecin Sodium 9
Cyclosporine 8
Florfenicol, Terbinafine Hcl, Mometasone Furoate 8
Carprofen 8
Bacitracin + Neomycin + Polymyxin B 7
Eye Medication (Unknown) 7
Fluid Therapy 7
Salicylic Acid 6

Neurogenic keratoconjunctivitis sicca (KCS) Reaction Insights

129 reports name Neurogenic keratoconjunctivitis sicca (KCS); 6 recorded a death outcome (4.7% of reported events, not a population-level mortality rate). VeDDRA code: 2866.

By species: Dog (129 reports). By breed: Shih Tzu (16), Chihuahua (10), Terrier - Rat (9).

Most co-reported drugs: Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (92 reports), Maropitant Citrate (27 reports), Prednisone (21 reports), Enrofloxacin (16 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.