Reaction profile

The FDA adverse-event record for excessive ear wax

95 FDA adverse-event reports reference excessive ear wax (VeDDRA 2759). See the species, breeds, and drugs most associated with it below.

95
reports citing this reaction
6.3%
death-coded share
Dog
most-affected species
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride
most-associated drug
Verify with FDA CVM →
95
Total Reports
6
Deaths
6.3%
Death Rate

Species Most Affected

Dog 78
Cat 17

Breeds Most Affected

Domestic Shorthair 16
Retriever - Labrador 10
Shiba Inu 4
Shih Tzu 4
Bulldog - French 4
Crossbred Canine/dog 4
Chihuahua 3
Dachshund - Miniature 2
Pug 2
American Pit Bull Terrier 2

Associated Drugs

Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 33
Maropitant Citrate 15
Gabapentin 13
Milbemycin Oxime + Spinosad 12
Oclacitinib Maleate 12
Prednisone 8
Enrofloxacin 8
Carprofen 8
Milbemycin Oxime + Praziquantel 7
Ear Cleaner (Unknown) 7
Cefpodoxime 6
Moxidectin 5
Anti-Il31 Mab Mcs Lot #1283563 5
Diphenhydramine 5
Fluid Therapy 5
Ketoconazole,Hydrocortisone 5
Afoxolaner 4
Trilostane 4
Rabies Vaccine 4
Bordetella Vaccine 4

Excessive ear wax Reaction Insights

95 reports name Excessive ear wax; 6 recorded a death outcome (6.3% of reported events, not a population-level mortality rate). VeDDRA code: 2759.

By species: Dog (78 reports), Cat (17 reports). By breed: Domestic Shorthair (16), Retriever - Labrador (10), Shiba Inu (4).

Most co-reported drugs: Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (33 reports), Maropitant Citrate (15 reports), Gabapentin (13 reports), Milbemycin Oxime + Spinosad (12 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.