Reaction profile

The FDA adverse-event record for necrotic wound

77 FDA adverse-event reports reference necrotic wound (VeDDRA 2890). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1521 of 2,481
by report volume (all reactions)
77
reports citing this reaction
15.6%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Necrotic wound has 77 reports now versus 75 in that prior snapshot: 2 more (2.7%).

Report change
+2
Death-coded reports
+0
Death-coded share
−0.4 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Necrotic wound changes

FDA AER · VeDDRA plate

Code 2890 VOL-LOW

VOL-LOW · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 77 reports
  • DEATH-ELEV 15.6%
  • MID-PACK #1521/2481
  • PHOTO-FINISH Application site twit…
  • SPECIES-DOG Dog · 63
  • DRUG-LEAD Tigilanol Tiglate · 36
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Application site twitching (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Necrotic wound

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Application site twit… · near77Cutaneous oedema · near77Dermal plaque · near77Drug preparation error · near77Necrotic wound · this reacti…77Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Necrotic wound

What the FDA AER plate says about Necrotic wound

Signature read: report volume at 77 (#1521 of 2,481) is the standout scale stamp on Necrotic wound. Report volume sits in the middle third of the reaction corpus. 12 of 77 reports were death-coded (15.6% of named reports, not a population mortality rate). Nearest volume peer: Application site twitching (±0 reports). Lead species Dog (63). Lead co-reported drug Tigilanol Tiglate (36).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Tigilanol Tiglate appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 63
Cat 9
Horse 4
Human 1

Breeds Most Affected

Retriever - Labrador 11
Domestic Shorthair 7
Pit Bull 5
Chihuahua 4
Retriever - Golden 4
Shepherd Dog - German 4
Bulldog - French 3
Boxer (German Boxer) 3
Pug 3
Shih Tzu 3

Associated Drugs

Tigilanol Tiglate 36
Carprofen 16
Butorphanol 14
Dexmedetomidine 13
Propofol 10
Isoflurane 8
Gabapentin 8
Buprenorphine 7
Bedinvetmab 7
Atipamezole 6
Dilute Chlorhexidine 5
Hydromorphone 5
Maropitant Citrate 4
Trazodone 4
Diphenhydramine 4
Frunevetmab 4
Amoxicillin Trihydrate;Clavulanate Potassium ( K-Clavulanate) 4
Ketamine 3
Dexmedetomidine Hydrochloride 3
Cefovecin 3

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Necrotic wound, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (77 here).

Similar death-coded share

Nearest other reactions by death-coded share (15.6% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Necrotic wound (#1521 of 2,481 by report volume); death-coded 15.6%. PlainBreed reaction plate · report volume stamp 77 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →