Reaction profile

The FDA adverse-event record for increased urine volume

143 FDA adverse-event reports reference increased urine volume (VeDDRA 2773). See the species, breeds, and drugs most associated with it below.

143
reports citing this reaction
16.1%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
143
Total Reports
23
Deaths
16.1%
Death Rate

Species Most Affected

Dog 123
Cat 18
Chicken 1
Sheep 1

Breeds Most Affected

Retriever - Labrador 14
Retriever - Golden 13
Domestic Shorthair 12
Terrier - Bull - American Pit 8
Dog (unknown) 7
Crossbred Canine/dog 5
Shepherd Dog - Australian 5
Shepherd Dog - German 5
Collie - Border 4
Shih Tzu 4

Associated Drugs

Bedinvetmab 61
Pyrantel Pamoate;Sarolaner 17
Carprofen 13
Maropitant Citrate 11
Gabapentin 11
Grapiprant 8
Fluralaner 13.64% 12-Week Chew 7
Bexagliflozin 7
Doxycycline 6
Prednisone 6
Galliprant 6
Oclacitinib Maleate 5
Lotilaner 5
Frunevetmab 5
Bordetella Bronchiseptica Vaccine, Avirulent Live Culture 5
Anti-Il31 Mab Mcs Lot #1283563 4
Prescription Diet 4
Cosequin 4
Borrelia Burgdorferi Bacterin-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract 4
Clopidogrel 4

Increased urine volume Reaction Insights

143 reports name Increased urine volume; 23 recorded a death outcome (16.1% of reported events, not a population-level mortality rate). VeDDRA code: 2773.

By species: Dog (123 reports), Cat (18 reports), Chicken (1 reports). By breed: Retriever - Labrador (14), Retriever - Golden (13), Domestic Shorthair (12).

Most co-reported drugs: Bedinvetmab (61 reports), Pyrantel Pamoate;Sarolaner (17 reports), Carprofen (13 reports), Maropitant Citrate (11 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.