Reaction profile

The FDA adverse-event record for loss of smell

56 FDA adverse-event reports reference loss of smell (VeDDRA 1592). See the species, breeds, and drugs most associated with it below.

56
reports citing this reaction
19.6%
death-coded share
Dog
most-affected species
Cefovecin
most-associated drug
Verify with FDA CVM →
56
Total Reports
11
Deaths
19.6%
Death Rate

Species Most Affected

Dog 41
Cat 15

Breeds Most Affected

Domestic Shorthair 8
Retriever - Labrador 4
Terrier - Jack Russell 4
Crossbred Canine/dog 3
Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) 2
Shepherd Dog - German 2
Chihuahua 2
Dog (unknown) 2
Siamese 2
Terrier - Scottish 1

Associated Drugs

Cefovecin 6
Maropitant Citrate 6
Oclacitinib Maleate 5
Spinosad 4
Carprofen 4
Trilostane 4
Mirtazapine 3
Gabapentin 3
Pyrantel Pamoate;Sarolaner 3
Bedinvetmab 3
Isoflurane 2
Milbemycin Oxime + Spinosad 2
Fluralaner Chew Tablets 2
Buprenorphine 2
Frunevetmab 2
Meloxicam 1
Dirlotapide 1
Tiletamine, Zolazepam 1
Milbemycin Oxime 1
Ivermectin 1

Loss of smell Reaction Insights

56 reports name Loss of smell; 11 recorded a death outcome (19.6% of reported events, not a population-level mortality rate). VeDDRA code: 1592.

By species: Dog (41 reports), Cat (15 reports). By breed: Domestic Shorthair (8), Retriever - Labrador (4), Terrier - Jack Russell (4).

Most co-reported drugs: Cefovecin (6 reports), Maropitant Citrate (6 reports), Oclacitinib Maleate (5 reports), Spinosad (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.