Reaction profile

The FDA adverse-event record for injection site sarcoma

86 FDA adverse-event reports reference injection site sarcoma (VeDDRA 101). See the species, breeds, and drugs most associated with it below.

86
reports citing this reaction
22.1%
death-coded share
Cat
most-affected species
Robenacoxib
most-associated drug
Verify with FDA CVM →
86
Total Reports
19
Deaths
22.1%
Death Rate

Species Most Affected

Cat 72
Dog 14

Breeds Most Affected

Domestic Shorthair 53
Domestic Longhair 8
Domestic Mediumhair 4
Siamese 3
Shih Tzu 3
Retriever - Labrador 3
Ocicat 1
Himalayan 1
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 1
Weimaraner 1

Associated Drugs

Robenacoxib 29
Cefovecin 23
Rabies Vaccine 19
Buprenorphine 18
Gabapentin 16
Maropitant Citrate 14
Rabies Vaccine, Killed Virus 12
Butorphanol 10
Frunevetmab 10
Propofol 9
Meloxicam 7
Rabies Virus, Kv 7
Cefovecin Sodium 7
Feline Leukemia Vaccine, Killed Virus 7
Fluid Therapy 7
Fvrcp Vaccine 6
Isoflurane 6
Dexmedetomidine 6
Ketamine 6
Midazolam 6

Injection site sarcoma Reaction Insights

86 reports name Injection site sarcoma; 19 recorded a death outcome (22.1% of reported events, not a population-level mortality rate). VeDDRA code: 101.

By species: Cat (72 reports), Dog (14 reports). By breed: Domestic Shorthair (53), Domestic Longhair (8), Domestic Mediumhair (4).

Most co-reported drugs: Robenacoxib (29 reports), Cefovecin (23 reports), Rabies Vaccine (19 reports), Buprenorphine (18 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.