Reaction profile

The FDA adverse-event record for lack of efficacy (neoplasia, no remission)

127 FDA adverse-event reports reference lack of efficacy (neoplasia, no remission) (VeDDRA 2891). See the species, breeds, and drugs most associated with it below.

127
reports citing this reaction
28.3%
death-coded share
Dog
most-affected species
Rabacfosadine
most-associated drug
Verify with FDA CVM →
127
Total Reports
36
Deaths
28.3%
Death Rate

Species Most Affected

Dog 127

Breeds Most Affected

Dog (unknown) 28
Retriever - Labrador 15
Retriever - Golden 9
Boxer (German Boxer) 6
Terrier - Boston 6
Terrier - Bull - American Pit 5
Pit Bull 5
Collie - Border 4
Mountain Dog - Bernese 3
Doberman Pinscher 2

Associated Drugs

Rabacfosadine 64
Prednisone 60
Tigilanol Tiglate 49
Maropitant Citrate 31
Gabapentin 28
Famotidine 27
Diphenhydramine 25
Butorphanol Tartrate 17
Dexmedetomidine 16
Verdinexor 13
Atipamezole 11
Butorphanol 10
Metronidazole 9
Atipamezole Hydrochloride 9
Dexmedetomidine Hydrochloride 8
Trazodone 7
Buprenorphine 5
Mirtazapine 5
Unspecified 5
Omeprazole 4

Lack of efficacy (neoplasia, no remission) Reaction Insights

127 reports name Lack of efficacy (neoplasia, no remission); 36 recorded a death outcome (28.3% of reported events, not a population-level mortality rate). VeDDRA code: 2891.

By species: Dog (127 reports). By breed: Dog (unknown) (28), Retriever - Labrador (15), Retriever - Golden (9).

Most co-reported drugs: Rabacfosadine (64 reports), Prednisone (60 reports), Tigilanol Tiglate (49 reports), Maropitant Citrate (31 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.