Reaction profile

The FDA adverse-event record for high pancreatic-specific lipase

799 FDA adverse-event reports reference high pancreatic-specific lipase (VeDDRA 2692). See the species, breeds, and drugs most associated with it below.

799
reports citing this reaction
15.8%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
799
Total Reports
126
Deaths
15.8%
Death Rate

Species Most Affected

Dog 541
Cat 258

Breeds Most Affected

Domestic Shorthair 167
Crossbred Canine/dog 51
Retriever - Labrador 37
Domestic Longhair 33
Terrier - Yorkshire 32
Chihuahua 29
Retriever - Golden 23
Shepherd Dog - Australian 16
Boxer (German Boxer) 16
Shih Tzu 16

Associated Drugs

Trilostane 140
Velagliflozin Proline Monohydrate 89
Bexagliflozin 86
Bedinvetmab 85
Maropitant Citrate 82
Gabapentin 56
Oclacitinib Maleate 45
Fluralaner 13.64% 12-Week Chew 38
Carprofen 36
Pyrantel Pamoate;Sarolaner 34
Insulin Injectable Vial 33
Grapiprant 32
Moxidectin 31
Frunevetmab 29
Afoxolaner 27
Prednisone 25
Enrofloxacin 23
Ivermectin + Pyrantel As Pamoate Salt 21
Cefovecin 21
Anti-Il31 Mab Mcs Lot #1283563 19

High pancreatic-specific lipase Reaction Insights

799 reports name High pancreatic-specific lipase; 126 recorded a death outcome (15.8% of reported events, not a population-level mortality rate). VeDDRA code: 2692.

By species: Dog (541 reports), Cat (258 reports). By breed: Domestic Shorthair (167), Crossbred Canine/dog (51), Retriever - Labrador (37).

Most co-reported drugs: Trilostane (140 reports), Velagliflozin Proline Monohydrate (89 reports), Bexagliflozin (86 reports), Bedinvetmab (85 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.