Reaction profile

The FDA adverse-event record for seal, abnormal

2,955 FDA adverse-event reports reference seal, abnormal (VeDDRA 99022). See the species, breeds, and drugs most associated with it below.

2,955
reports citing this reaction
0.0%
death-coded share
Unknown
most-affected species
Ivermectin + Pyrantel As Pamoate Salt
most-associated drug
Verify with FDA CVM →
2,955
Total Reports
0
Deaths
0.0%
Death Rate

Species Most Affected

Unknown 2,916
Dog 14
Human 14
Cat 9
Cattle 2

Breeds Most Affected

Unknown 2,931
Cat (unknown) 4
Spaniel - Cocker American 2
Domestic Shorthair 2
Chihuahua 2
Dog (unknown) 2
Domestic (unspecified) 1
Cattle (unknown) 1
Japanese Chin (Spaniel) 1
Pinscher - Miniature 1

Associated Drugs

Ivermectin + Pyrantel As Pamoate Salt 318
Meloxicam 205
Moxidectin 174
Carprofen 159
Ivermectin, Pyrantel 121
Amoxicillin Trihydrate;Clavulanate Potassium ( K-Clavulanate) 108
Amoxicillin, Clavulanate 87
Clindamycin Hydrochloride 80
Doramectin 53
Selamectin 50
Enrofloxacin 49
Protamine Zinc Recombinant Human Insulin 47
Fluralaner Spot-On Solution 47
Pimobendan 44
Ivermectin 40
Grapiprant 39
Cyclosporine 35
Altrenogest Oily Solution 34
Afoxolaner 34
Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate) 33

Seal, Abnormal Reaction Insights

2,955 reports name Seal, Abnormal; 0 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). VeDDRA code: 99022.

By species: Unknown (2,916 reports), Dog (14 reports), Human (14 reports). By breed: Unknown (2,931), Cat (unknown) (4), Spaniel - Cocker American (2).

Most co-reported drugs: Ivermectin + Pyrantel As Pamoate Salt (318 reports), Meloxicam (205 reports), Moxidectin (174 reports), Carprofen (159 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.