Reaction profile

The FDA adverse-event record for skin oedema

194 FDA adverse-event reports reference skin oedema (VeDDRA 968). See the species, breeds, and drugs most associated with it below.

194
reports citing this reaction
18.0%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
194
Total Reports
35
Deaths
18.0%
Death Rate

Species Most Affected

Dog 141
Cat 22
Human 11
Horse 10
Rabbit 8
Cattle 1
Chicken 1

Breeds Most Affected

Retriever - Labrador 20
Domestic Shorthair 14
Unknown 13
Pit Bull 9
Crossbred Canine/dog 8
Boxer (German Boxer) 8
Chihuahua 8
Retriever - Golden 8
Shepherd Dog - German 6
Crossbred rabbit 6

Associated Drugs

Carprofen 27
Meloxicam 21
Tigilanol Tiglate 17
Milbemycin Oxime + Spinosad 16
Prednisone 15
Maropitant Citrate 14
Cefovecin 11
Isoflurane 10
Fluralaner Chew Tablets 10
Unspecified 10
Oclacitinib Maleate 9
Midazolam 9
Butorphanol 8
Gabapentin 8
Moxidectin 8
Dexmedetomidine Hydrochloride 7
Ketamine Hydrochloride 7
Buprenorphine 6
Famotidine 6
Enrofloxacin 6

Skin oedema Reaction Insights

194 reports name Skin oedema; 35 recorded a death outcome (18.0% of reported events, not a population-level mortality rate). VeDDRA code: 968.

By species: Dog (141 reports), Cat (22 reports), Human (11 reports). By breed: Retriever - Labrador (20), Domestic Shorthair (14), Unknown (13).

Most co-reported drugs: Carprofen (27 reports), Meloxicam (21 reports), Tigilanol Tiglate (17 reports), Milbemycin Oxime + Spinosad (16 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.