Reaction profile

The FDA adverse-event record for injection site erythema

385 FDA adverse-event reports reference injection site erythema (VeDDRA 77). See the species, breeds, and drugs most associated with it below.

385
reports citing this reaction
3.9%
death-coded share
Dog
most-affected species
Tigilanol Tiglate
most-associated drug
Verify with FDA CVM →
385
Total Reports
15
Deaths
3.9%
Death Rate

Species Most Affected

Dog 278
Human 56
Cat 42
Pig 2
Horse 2
Cattle 1
Rat 1
Sheep 1
Rabbit 1
Mouse 1

Breeds Most Affected

Unknown 58
Retriever - Labrador 34
Domestic Shorthair 28
Pit Bull 27
Crossbred Canine/dog 15
Boxer (German Boxer) 13
Retriever - Golden 12
Chihuahua 10
Terrier - Bull - American Pit 9
Shepherd Dog - German 9

Associated Drugs

Tigilanol Tiglate 129
Carprofen 36
Maropitant Citrate 34
Diphenhydramine 33
Gabapentin 30
Famotidine 30
Prednisone 29
Buprenorphine 25
Enrofloxacin 24
Butorphanol 24
Melarsomine Dihydrochloride 22
Moxidectin 21
Cefovecin 18
Atipamezole 16
Dexmedetomidine 15
Propofol 14
Butorphanol Tartrate 14
Dexmedetomidine Hydrochloride 14
Praziquantel 13
Bedinvetmab 12

Injection site erythema Reaction Insights

385 reports name Injection site erythema; 15 recorded a death outcome (3.9% of reported events, not a population-level mortality rate). VeDDRA code: 77.

By species: Dog (278 reports), Human (56 reports), Cat (42 reports). By breed: Unknown (58), Retriever - Labrador (34), Domestic Shorthair (28).

Most co-reported drugs: Tigilanol Tiglate (129 reports), Carprofen (36 reports), Maropitant Citrate (34 reports), Diphenhydramine (33 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.