Reaction profile

The FDA adverse-event record for immediate pain upon application

72 FDA adverse-event reports reference immediate pain upon application (VeDDRA 2408). See the species, breeds, and drugs most associated with it below.

72
reports citing this reaction
0.0%
death-coded share
Cat
most-affected species
Selamectin
most-associated drug
Verify with FDA CVM →
72
Total Reports
0
Deaths
0.0%
Death Rate

Species Most Affected

Cat 50
Dog 21
Goat 1

Breeds Most Affected

Domestic Shorthair 29
Cat (other) 8
Dog (unknown) 4
Domestic Mediumhair 3
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 2
Cat (unknown) 2
Ragdoll 2
Bulldog - French 1
Dachshund (unspecified) 1
Persian 1

Associated Drugs

Selamectin 34
Selamectin;Sarolaner 16
Florfenicol, Terbinafine, Betamethasone Acetate 5
Fluralaner Spot-On Solution 3
Oclacitinib Maleate 2
Gentamicin Sulfate + Hydrocortisone Aceponate + Miconazole Nitrate 2
Cefovecin 1
Bacitracin + Neomycin + Polymyxin 1
Fluorescein Stain 1
Hyaluronic Acid 1
Tobramycin 1
Antibiotic 1
Artificial Tear Solution 1
Unknown Ocular Solution 1
Dimethyl Sulfoxide;Fluocinolone Acetonide 1
Enrofloxacin & Silver Sulfadiazine 1
Gentamicin, Mometasone Furoate, And Clotrimazole 1
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 1
Rabies Vaccine 1
Distemper Parvo Vaccine 1

Immediate pain upon application Reaction Insights

72 reports name Immediate pain upon application; 0 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). VeDDRA code: 2408.

By species: Cat (50 reports), Dog (21 reports), Goat (1 reports). By breed: Domestic Shorthair (29), Cat (other) (8), Dog (unknown) (4).

Most co-reported drugs: Selamectin (34 reports), Selamectin;Sarolaner (16 reports), Florfenicol, Terbinafine, Betamethasone Acetate (5 reports), Fluralaner Spot-On Solution (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.