Reaction profile
The FDA adverse-event record for immediate pain upon application
72 FDA adverse-event reports reference immediate pain upon application (VeDDRA 2408). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.
- #1558 of 2,481
- by report volume (all reactions)
- 72
- reports citing this reaction
- 0.0%
- death-coded share
- Cat
- most-affected species
Release-over-release change
What changed in the latest FDA data snapshot
PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Immediate pain upon application has 72 reports now versus 72 in that prior snapshot: 0 the same number of (0.0%).
- Report change
- +0
- Death-coded reports
- +0
- Death-coded share
- +0.0 pts
This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.
Subscribe to Immediate pain upon application changesFDA AER · VeDDRA plate
Code 2408 VOL-LOW
VOL-LOW · DEATH-RARE · MID-PACK · PHOTO-FINISH · SPECIES-CAT · DRUG-LEAD · DESK-WIDE · BOOK-FULL
- VOL-LOW 72 reports
- DEATH-RARE 0.0%
- MID-PACK #1558/2481
- PHOTO-FINISH Ear flapping/twitching
- SPECIES-CAT Cat · 50
- DRUG-LEAD Selamectin · 34
- DESK-WIDE 20 breeds
- BOOK-FULL 8/8 fields
Nearest volume peer: Ear flapping/twitching (±0 reports)
Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.
Report-volume neighbourhood around Immediate pain upon application
Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.
Immediate pain upon application: low death-coded share in the FDA AER plate
Signature read: Immediate pain upon application's 0.0% death-coded share is among the lowest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is lower-third: 0 of 72 reports (0.0% of named reports). Nearest volume peer: Ear flapping/twitching (±0 reports). Lead species Cat (50). Lead co-reported drug Selamectin (34).
Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Selamectin appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.
Species Most Affected
Breeds Most Affected
Associated Drugs
Nationwide reactions with similar profiles
Two openFDA-derived peer sets for Immediate pain upon application, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).
Similar report volume
Nearest other reactions by FDA report count (72 here).
Similar death-coded share
Nearest other reactions by death-coded share (0.0% here), distinct from the volume row.
What to do with this reaction
- Compare Immediate pain upon application's report profile against similar reactions nationwide. See similar reactions
- Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
- Browse the full reaction directory to compare report counts across reaction types. All reactions
A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.
Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025
Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →