Reaction profile

The FDA adverse-event record for hyperglycaemia

5,782 FDA adverse-event reports reference hyperglycaemia (VeDDRA 1946). See the species, breeds, and drugs most associated with it below.

5,782
reports citing this reaction
21.2%
death-coded share
Dog
most-affected species
Bexagliflozin
most-associated drug
Verify with FDA CVM →
5,782
Total Reports
1,227
Deaths
21.2%
Death Rate

Species Most Affected

Dog 3,530
Cat 2,178
Horse 56
Human 11
Ferret 3
Cattle 2
Monkey 1
Wolf 1

Breeds Most Affected

Domestic Shorthair 1,278
Retriever - Labrador 336
Crossbred Canine/dog 266
Chihuahua 253
Domestic (unspecified) 224
Terrier - Yorkshire 174
Domestic Longhair 164
Cat (unknown) 142
Shih Tzu 129
Maltese 128

Associated Drugs

Bexagliflozin 726
Trilostane 705
Maropitant Citrate 397
Milbemycin Oxime + Spinosad 390
Carprofen 280
Insulin 240
Afoxolaner 230
Spinosad 218
Cefovecin 216
Insulin Injectable Vial 209
Oclacitinib Maleate 184
Meloxicam 182
Buprenorphine 167
Fluralaner Chew Tablets 167
Gabapentin 166
Ivermectin + Pyrantel As Pamoate Salt 141
Prednisone 135
Moxidectin 127
Human Insulin 124
Cyclosporine 123

Hyperglycaemia Reaction Insights

5,782 reports name Hyperglycaemia; 1,227 recorded a death outcome (21.2% of reported events, not a population-level mortality rate). VeDDRA code: 1946.

By species: Dog (3,530 reports), Cat (2,178 reports), Horse (56 reports). By breed: Domestic Shorthair (1,278), Retriever - Labrador (336), Crossbred Canine/dog (266).

Most co-reported drugs: Bexagliflozin (726 reports), Trilostane (705 reports), Maropitant Citrate (397 reports), Milbemycin Oxime + Spinosad (390 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.