Reaction profile

The FDA adverse-event record for hyperglycaemia

6,174 FDA reports name hyperglycaemia, a high-volume reaction in the CVM extract (VeDDRA 1946). Plate stamps and neighbourhood peers follow.

#83 of 2,481
by report volume (all reactions)
6,174
reports citing this reaction
21.4%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hyperglycaemia has 6,174 reports now versus 6,008 in that prior snapshot: 166 more (2.8%).

Report change
+166
Death-coded reports
+32
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hyperglycaemia changes

FDA AER · VeDDRA plate

Code 1946 VOL-HIGH

VOL-HIGH · DEATH-HOT · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-HIGH 6,174 reports
  • DEATH-HOT 21.4%
  • TOP-DECILE #83/2481
  • PHOTO-FINISH Not drinking
  • SPECIES-DOG Dog · 3,685
  • DRUG-LEAD Bexagliflozin · 849
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Not drinking (±47 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Hyperglycaemia

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Weight gain · near6282Pale mucous membrane · near6258Not drinking · near6221Hyperglycaemia · this reacti…6174Lack of efficacy (tic… · near6102Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Hyperglycaemia

What the FDA AER plate says about Hyperglycaemia

Signature read: 1,322 death-coded reports is a heavy tail count for Hyperglycaemia in the CVM extract. Report volume is upper-third scale: 6,174 named reports in the openFDA extract. 1,322 of 6,174 reports were death-coded (21.4% of named reports, not a population mortality rate). Nearest volume peer: Not drinking (±47 reports). Lead species Dog (3,685). Lead co-reported drug Bexagliflozin (849).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Bexagliflozin appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 3,685
Cat 2,405
Horse 65
Human 11
Ferret 3
Cattle 2
Monkey 1
Wolf 1
Goat 1

Breeds Most Affected

Domestic Shorthair 1,434
Retriever - Labrador 355
Crossbred Canine/dog 277
Chihuahua 264
Domestic (unspecified) 224
Domestic Longhair 182
Terrier - Yorkshire 177
Cat (unknown) 157
Shih Tzu 133
Maltese 131

Associated Drugs

Bexagliflozin 849
Trilostane 739
Maropitant Citrate 472
Milbemycin Oxime + Spinosad 391
Carprofen 299
Insulin 256
Cefovecin 238
Afoxolaner 235
Spinosad 218
Insulin Injectable Vial 210
Oclacitinib Maleate 197
Gabapentin 196
Meloxicam 192
Buprenorphine 190
Fluralaner Chew Tablets 167
Prednisone 150
Ivermectin + Pyrantel As Pamoate Salt 144
Moxidectin 140
Cefovecin Sodium 139
Frunevetmab 136

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Hyperglycaemia, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (6,174 here).

Similar death-coded share

Nearest other reactions by death-coded share (21.4% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hyperglycaemia (#83 of 2,481 by report volume); death-coded 21.4%. PlainBreed reaction plate · death-coded report count stamp 1,322 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →