Reaction profile

The FDA adverse-event record for bradycardia

2,571 FDA adverse-event reports reference bradycardia (VeDDRA 188). See the species, breeds, and drugs most associated with it below.

2,571
reports citing this reaction
21.7%
death-coded share
Dog
most-affected species
Dexmedetomidine Hydrochloride
most-associated drug
Verify with FDA CVM →
2,571
Total Reports
557
Deaths
21.7%
Death Rate

Species Most Affected

Dog 2,033
Cat 471
Horse 25
Human 14
Rabbit 9
Monkey 4
Turtle 3
Cattle 2
Other 2
Goat 1

Breeds Most Affected

Domestic Shorthair 195
Dog (unknown) 150
Retriever - Labrador 141
Crossbred Canine/dog 114
Shih Tzu 110
Chihuahua 94
Terrier - Yorkshire 79
Cat (unknown) 72
Shepherd Dog - Australian 64
Boxer (German Boxer) 58

Associated Drugs

Dexmedetomidine Hydrochloride 501
Isoflurane 333
Propofol 264
Butorphanol 233
Maropitant Citrate 223
Moxidectin 211
Atipamezole Hydrochloride 168
Butorphanol Tartrate 147
Buprenorphine 138
Milbemycin Oxime + Spinosad 125
Dexmedetomidine 124
Carprofen 122
Ketamine 122
Atropine 83
Gabapentin 79
Midazolam 71
Alfaxalone 71
Sevoflurane 70
Capromorelin Tartrate 65
Cefovecin 64

Bradycardia Reaction Insights

2,571 reports name Bradycardia; 557 recorded a death outcome (21.7% of reported events, not a population-level mortality rate). VeDDRA code: 188.

By species: Dog (2,033 reports), Cat (471 reports), Horse (25 reports). By breed: Domestic Shorthair (195), Dog (unknown) (150), Retriever - Labrador (141).

Most co-reported drugs: Dexmedetomidine Hydrochloride (501 reports), Isoflurane (333 reports), Propofol (264 reports), Butorphanol (233 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.