Gut sounds increased

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VeDDRA Code: 1890

353 adverse event reports referencing this reaction

353
Total Reports
14
Deaths
400.0%
Death Rate

Species Most Affected

Dog 325
Horse 17
Cat 11

Breeds Most Affected

Crossbred Canine/dog 37
Retriever - Labrador 21
Chihuahua 15
Greyhound 13
Retriever - Golden 11
Boxer (German Boxer) 10
Shepherd Dog - German 10
Terrier - Yorkshire 8
Dachshund (unspecified) 8
Terrier - West Highland White 8

Associated Drugs

Milbemycin Oxime + Spinosad 75
Spinosad 24
Ivermectin + Pyrantel As Pamoate Salt 24
Milbemycin Oxime + Praziquantel 15
Carprofen 13
Grapiprant 13
Pyrantel Pamoate;Sarolaner 12
Cyclosporine 11
Maropitant Citrate 11
Fenbendazole 10
Rabies Vaccine 10
Ivermectin, Pyrantel 9
Afoxolaner 9
Milbemycin 8
Fluralaner 13.64% 12-Week Chew 8
Metronidazole 7
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 7
Oclacitinib Maleate 7
Moxidectin 6
Selamectin 5

Data Summary

Metric Value
Total reports referencing reaction 353
Reports with fatal outcome 14
Case-fatality rate (reported events) 400.0%
Species observed 3
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 1890.

Gut sounds increased Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 353 adverse event reports that reference Gut sounds increased as a reaction term, including 14 reports with a death outcome — a 400.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 1890, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Gut sounds increased appears most frequently in reports for Dog (325 reports), Horse (17 reports), Cat (11 reports) — with Dog dominating at 325 entries. Within those species, the breeds most often named alongside this reaction are Crossbred Canine/dog (37), Retriever - Labrador (21), Chihuahua (15). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Gut sounds increased are Milbemycin Oxime + Spinosad (75 reports), Spinosad (24 reports), Ivermectin + Pyrantel As Pamoate Salt (24 reports), Milbemycin Oxime + Praziquantel (15 reports), with Milbemycin Oxime + Spinosad appearing alongside this reaction in 75 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial