Reaction profile

The FDA adverse-event record for gut sounds increased

353 FDA adverse-event reports reference gut sounds increased (VeDDRA 1890). See the species, breeds, and drugs most associated with it below.

353
reports citing this reaction
4.0%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
353
Total Reports
14
Deaths
4.0%
Death Rate

Species Most Affected

Dog 325
Horse 17
Cat 11

Breeds Most Affected

Crossbred Canine/dog 37
Retriever - Labrador 21
Chihuahua 15
Greyhound 13
Retriever - Golden 11
Boxer (German Boxer) 10
Shepherd Dog - German 10
Terrier - Yorkshire 8
Dachshund (unspecified) 8
Terrier - West Highland White 8

Associated Drugs

Milbemycin Oxime + Spinosad 75
Spinosad 24
Ivermectin + Pyrantel As Pamoate Salt 24
Milbemycin Oxime + Praziquantel 15
Carprofen 13
Grapiprant 13
Pyrantel Pamoate;Sarolaner 12
Cyclosporine 11
Maropitant Citrate 11
Fenbendazole 10
Rabies Vaccine 10
Ivermectin, Pyrantel 9
Afoxolaner 9
Milbemycin 8
Fluralaner 13.64% 12-Week Chew 8
Metronidazole 7
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 7
Oclacitinib Maleate 7
Moxidectin 6
Selamectin 5

Gut sounds increased Reaction Insights

353 reports name Gut sounds increased; 14 recorded a death outcome (4.0% of reported events, not a population-level mortality rate). VeDDRA code: 1890.

By species: Dog (325 reports), Horse (17 reports), Cat (11 reports). By breed: Crossbred Canine/dog (37), Retriever - Labrador (21), Chihuahua (15).

Most co-reported drugs: Milbemycin Oxime + Spinosad (75 reports), Spinosad (24 reports), Ivermectin + Pyrantel As Pamoate Salt (24 reports), Milbemycin Oxime + Praziquantel (15 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.