Reaction profile

The FDA adverse-event record for fracture

271 FDA adverse-event reports reference fracture (VeDDRA 585). See the species, breeds, and drugs most associated with it below.

271
reports citing this reaction
38.4%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
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271
Total Reports
104
Deaths
38.4%
Death Rate

Species Most Affected

Dog 171
Cat 45
Cattle 20
Horse 15
Pig 8
Unknown 5
Chicken 3
Human 2
Rabbit 1
Cougar 1

Breeds Most Affected

Domestic Shorthair 22
Retriever - Labrador 21
Retriever - Golden 14
Shepherd Dog - German 13
Crossbred Canine/dog 12
Unknown 10
Cat (other) 7
Cat (unknown) 6
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 6
Shepherd Dog - Australian 6

Associated Drugs

Milbemycin Oxime + Spinosad 65
Bedinvetmab 40
Carprofen 23
Frunevetmab 22
Gabapentin 21
Milbemycin Oxime + Praziquantel 19
Oclacitinib Maleate 12
Buprenorphine 11
Spinosad 10
Prednisone 10
Fluralaner 13.64% 12-Week Chew 8
Ivermectin 7
Cephalexin 7
Doxycycline 7
Afoxolaner 7
Deracoxib 7
Clodronate Disodium 7
Ivermectin + Pyrantel As Pamoate Salt 7
Ractopamine Hydrochloride 6
Butorphanol 6

Fracture Reaction Insights

271 reports name Fracture; 104 recorded a death outcome (38.4% of reported events, not a population-level mortality rate). VeDDRA code: 585.

By species: Dog (171 reports), Cat (45 reports), Cattle (20 reports). By breed: Domestic Shorthair (22), Retriever - Labrador (21), Retriever - Golden (14).

Most co-reported drugs: Milbemycin Oxime + Spinosad (65 reports), Bedinvetmab (40 reports), Carprofen (23 reports), Frunevetmab (22 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.