Reaction profile

The FDA adverse-event record for fracture

Name: Fracture - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

297 FDA adverse-event reports reference fracture (VeDDRA 585). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#869 of 2,481
by report volume (all reactions): 297
reports citing this reaction: 38.4%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Fracture has 297 reports now versus 286 in that prior snapshot: 11 more (3.8%).

Report change: +11
Death-coded reports: +3
Death-coded share: −0.4 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Fracture changes

FDA AER · VeDDRA plate

Code 585 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-LOW 297 reports
DEATH-HOT 38.4%
MID-PACK #869/2481
PHOTO-FINISH DEATH-TREATMENT FAILU…
SPECIES-DOG Dog · 192
DRUG-LEAD Milbemycin Oxime… · 65
DESK-WIDE 20 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: DEATH-TREATMENT FAILURE (±2 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Fracture

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

FDA AER report volume · neighbourhood around Fracture

Fracture: high death-coded share in the FDA AER plate

Signature read: 114 death-coded reports is a heavy tail count for Fracture in the CVM extract. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 114 of 297 reports (38.4% of named reports). Nearest volume peer: DEATH-TREATMENT FAILURE (±2 reports). Lead species Dog (192). Lead co-reported drug Milbemycin Oxime + Spinosad (65).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 192

Cat 46

Cattle 23

Horse 16

Pig 8

Unknown 5

Chicken 3

Human 2

Rabbit 1

Cougar 1

Breeds Most Affected

Retriever - Labrador 24

Domestic Shorthair 23

Retriever - Golden 15

Crossbred Canine/dog 13

Shepherd Dog - German 13

Unknown 11

Cat (unknown) 7

Chihuahua 7

Cattle (other) 6

Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 6

Associated Drugs

Milbemycin Oxime + Spinosad 65

Bedinvetmab 55

Carprofen 32

Gabapentin 30

Frunevetmab 23

Milbemycin Oxime + Praziquantel 20

Buprenorphine 14

Oclacitinib Maleate 13

Spinosad 10

Prednisone 10

Cephalexin 9

Deracoxib 9

Polysulfated Glycosaminoglycan 8

Fluralaner 13.64% 12-Week Chew 8

Ivermectin 7

Doxycycline 7

Afoxolaner 7

Clodronate Disodium 7

Milbemycin Oxime 7

Maropitant Citrate 7

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Fracture, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (297 here).

DEATH-TREATMENT FAILURE 295 Abortion 294 Exercise intolerance 294 Lack of efficacy (ectoparasite) - Sarcoptes 300

Similar death-coded share

Nearest other reactions by death-coded share (38.4% here), distinct from the volume row.

Stillbirth 38.3% Other coagulation abnormality NOS 38.5% Cold feeling to the touch 38.2% Ventricular arrhythmia 38.1%

What to do with this reaction

Compare Fracture's report profile against similar reactions nationwide. See similar reactions
Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Fracture (#869 of 2,481 by report volume); death-coded 38.4%. PlainBreed reaction plate · death-coded report count stamp 114 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →