Reaction profile

The FDA adverse-event record for death-treatment failure

295 FDA adverse-event reports reference death-treatment failure (VeDDRA 99941). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#870 of 2,481
by report volume (all reactions)
295
reports citing this reaction
99.7%
death-coded share
Cattle
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. DEATH-TREATMENT FAILURE has 295 reports now versus 295 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to DEATH-TREATMENT FAILURE changes

FDA AER · VeDDRA plate

Code 99941 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-CATTLE · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 295 reports
  • DEATH-HOT 99.7%
  • MID-PACK #870/2481
  • PHOTO-FINISH Abortion
  • SPECIES-CATTLE Cattle · 271
  • DRUG-LEAD Tildipirosin · 70
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Abortion (±1 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around DEATH-TREATMENT FAILURE

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348DEATH-TREATMENT FAILU… · thi…295Abortion · near294Exercise intolerance · near294Residues in meat/offal · near294Anaphylactic shock · near293Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around DEATH-TREATMENT FAILURE

DEATH-TREATMENT FAILURE: high death-coded share in the FDA AER plate

Signature read: DEATH-TREATMENT FAILURE's 99.7% death-coded share is among the highest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 294 of 295 reports (99.7% of named reports). Nearest volume peer: Abortion (±1 reports). Lead species Cattle (271). Lead co-reported drug Tildipirosin (70).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Cattle 271
Dog 7
Horse 6
Pig 3
Chicken 2
Goat 2
Sheep 1
Cat 1
Fish 1
Other Birds 1

Breeds Most Affected

Cattle (unknown) 87
Crossbred Bovine/Cattle 87
Holstein-Friesian also known as Holstein 48
Cattle (other) 19
Aberdeen Angus 19
Unknown 10
Crossbred Porcine/Pig 3
Mixed (Cattle) 3
Bulldog 2
Chicken (unknown) 2

Associated Drugs

Tildipirosin 70
Tulathromycin 61
Ceftiofur 47
Florfenicol, Flunixin 42
Ceftiofur Crystalline Free Acid 16
Bovine Parainfluenza Virus 3 (Ts), Rlb103 (Nl-Bk-6), Mlv; Bovine Respiratory Syn 11
Vaccine 11
Tildipirosin Injectable 11
Florfenicol 9
Bovine Parainfluenza Virus 3, Reisinger(Nl-Bk-6), Mlv; Bovine Respiratory Syncyt 8
Clostridium Chauvoei, F, Kb; Clostridium Novyi, 8296, Kb; Clostridium Perfringen 6
Ivermectin 5
Bovine Viral Diarrhea Virus, 53637, Bvd2Mlv-D; Bovine Viral Diarrhea Virus, Nadl 5
Gamithromycin 5
Pyrantel Pamoate 4
Tilmicosin Phosphate 4
Mannheimia Haemolytica Type A1, Nl-1009, Capsular Antigen, Kb; Mannheimia Haemol 4
Doramectin 4
Gamithromycin 15% 4
Gamithromycin 15% Injection 4

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for DEATH-TREATMENT FAILURE, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (295 here).

Similar death-coded share

Nearest other reactions by death-coded share (99.7% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for DEATH-TREATMENT FAILURE (#870 of 2,481 by report volume); death-coded 99.7%. PlainBreed reaction plate · death-coded share stamp 99.7% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →