Reaction profile

The FDA adverse-event record for fear/fearful

86 FDA adverse-event reports reference fear/fearful (VeDDRA 3062). See the species, breeds, and drugs most associated with it below.

86
reports citing this reaction
8.1%
death-coded share
Dog
most-affected species
Pyrantel Pamoate;Sarolaner
most-associated drug
Verify with FDA CVM →
86
Total Reports
7
Deaths
8.1%
Death Rate

Species Most Affected

Dog 68
Cat 17
Horse 1

Breeds Most Affected

Domestic Shorthair 10
Dog (unknown) 5
Crossbred Canine/dog 5
Shepherd Dog - German 4
Retriever - Labrador 4
Retriever - Golden 3
Chihuahua 3
Pointing Dog - German Short-haired 2
Bulldog - French 2
Terrier - Yorkshire 2

Associated Drugs

Pyrantel Pamoate;Sarolaner 11
Bedinvetmab 9
Milbemycin Oxime + Praziquantel 8
Buprenorphine 8
Afoxolaner 7
Fluralaner 13.64% 12-Week Chew 6
Ivermectin + Pyrantel As Pamoate Salt 6
Lotilaner 4
Cefovecin Sodium 4
Gabapentin 4
Sedative (Unknown) 4
Milbemycin Oxime 3
Fluralaner 3
Sarolaner 3
Trazodone 3
Maropitant Citrate 3
Probiotic (Active Ingredients Unknown) 3
Selamectin;Sarolaner 3
Carprofen 2
Fipronil + S-Methoprene 2

Fear/fearful Reaction Insights

86 reports name Fear/fearful; 7 recorded a death outcome (8.1% of reported events, not a population-level mortality rate). VeDDRA code: 3062.

By species: Dog (68 reports), Cat (17 reports), Horse (1 reports). By breed: Domestic Shorthair (10), Dog (unknown) (5), Crossbred Canine/dog (5).

Most co-reported drugs: Pyrantel Pamoate;Sarolaner (11 reports), Bedinvetmab (9 reports), Milbemycin Oxime + Praziquantel (8 reports), Buprenorphine (8 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.