Reaction profile

The FDA adverse-event record for facial swelling (see also 'skin')

6,644 FDA adverse-event reports reference facial swelling (see also 'skin') (VeDDRA 517). See the species, breeds, and drugs most associated with it below.

6,644
reports citing this reaction
1.2%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
6,644
Total Reports
81
Deaths
1.2%
Death Rate

Species Most Affected

Dog 6,349
Cat 182
Horse 77
Human 20
Cattle 14
Other 1
Ferret 1

Breeds Most Affected

Retriever - Labrador 684
Terrier - Bull - American Pit 600
Chihuahua 454
Boxer (German Boxer) 400
Crossbred Canine/dog 255
Dachshund (unspecified) 226
Retriever - Golden 208
Pug 180
Shepherd Dog - German 160
Siberian Husky 159

Associated Drugs

Moxidectin 3,671
Rabies Virus, 544
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 492
Maropitant Citrate 392
Milbemycin Oxime + Spinosad 351
Diphenhydramine Hcl 323
Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 282
Rabies Virus, Kv 246
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 245
Afoxolaner 227
Carprofen 191
Oclacitinib Maleate 186
Anti-Il31 Mab Mcs Lot #1283563 176
Dexamethasone 163
Canine Parvovirus Strain Nl-35-D, P.35-D, 8-2-80;Canine Parainfluenza Virus, Str 162
Recombinant E. Coli Bl21;Recombinant E. Coli Ecl19 154
Melarsomine Dihydrochloride 152
Milbemycin Oxime + Praziquantel 145
Pyrantel Pamoate;Sarolaner 140
Prednisone 131

Facial swelling (see also 'Skin') Reaction Insights

6,644 reports name Facial swelling (see also 'Skin'); 81 recorded a death outcome (1.2% of reported events, not a population-level mortality rate). VeDDRA code: 517.

By species: Dog (6,349 reports), Cat (182 reports), Horse (77 reports). By breed: Retriever - Labrador (684), Terrier - Bull - American Pit (600), Chihuahua (454).

Most co-reported drugs: Moxidectin (3,671 reports), Rabies Virus, (544 reports), Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str (492 reports), Maropitant Citrate (392 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.