Reaction profile

The FDA adverse-event record for epileptic seizure

209 FDA adverse-event reports reference epileptic seizure (VeDDRA 648). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1012 of 2,481
by report volume (all reactions)
209
reports citing this reaction
9.1%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Epileptic seizure has 209 reports now versus 207 in that prior snapshot: 2 more (1.0%).

Report change
+2
Death-coded reports
+2
Death-coded share
+0.9 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Epileptic seizure changes

FDA AER · VeDDRA plate

Code 648 VOL-LOW

VOL-LOW · DEATH-PAR · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 209 reports
  • DEATH-PAR 9.1%
  • MID-PACK #1012/2481
  • PHOTO-FINISH Drug prescribing error
  • SPECIES-DOG Dog · 201
  • DRUG-LEAD Milbemycin Oxime… · 62
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Drug prescribing error (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Epileptic seizure

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Drug prescribing error · near209Epilepsy · near209Epileptic seizure · this rea…209Puncture wound · near209Application site hair… · near208Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Epileptic seizure

What the FDA AER plate says about Epileptic seizure

Signature read: death-coded share at 9.1% is the most distinctive outcome stamp on Epileptic seizure. Report volume sits in the middle third of the reaction corpus. 19 of 209 reports were death-coded (9.1% of named reports, not a population mortality rate). Nearest volume peer: Drug prescribing error (±0 reports). Lead species Dog (201). Lead co-reported drug Milbemycin Oxime + Spinosad (62).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 201
Cat 6
Horse 2

Breeds Most Affected

Retriever - Labrador 21
Terrier - Yorkshire 12
Beagle 11
Retriever - Golden 11
Chihuahua 10
Collie - Border 10
Crossbred Canine/dog 10
Shepherd Dog - German 9
Shepherd Dog - Australian 7
Spitz - German Pomeranian 7

Associated Drugs

Milbemycin Oxime + Spinosad 62
Fluralaner Chew Tablets 29
Phenobarbital 26
Spinosad 25
Unspecified 17
Afoxolaner 68 Mg Chewable Tablets 8
Carprofen 6
Afoxolaner 28.3 Mg Chewable Tablets 6
Milbemycin Oxime + Praziquantel 6
Levetiracetam 5
Trilostane 5
Moxidectin 5
Afoxolaner 136 Mg Chewable Tablets 5
Imidacloprid + Moxidectin 4
Ivermectin 4
Levothyroxine Sodium 4
Zonisamide 4
Prednisone 4
Meloxicam 4
Potassium Bromide 3

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Epileptic seizure, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (209 here).

Similar death-coded share

Nearest other reactions by death-coded share (9.1% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Epileptic seizure (#1012 of 2,481 by report volume); death-coded 9.1%. PlainBreed reaction plate · death-coded share stamp 9.1% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →