Reaction profile

The FDA adverse-event record for epileptic seizure

205 FDA adverse-event reports reference epileptic seizure (VeDDRA 648). See the species, breeds, and drugs most associated with it below.

205
reports citing this reaction
7.8%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
205
Total Reports
16
Deaths
7.8%
Death Rate

Species Most Affected

Dog 197
Cat 6
Horse 2

Breeds Most Affected

Retriever - Labrador 20
Terrier - Yorkshire 12
Beagle 11
Retriever - Golden 11
Collie - Border 10
Crossbred Canine/dog 10
Shepherd Dog - German 9
Chihuahua 8
Shepherd Dog - Australian 7
Spitz - German Pomeranian 7

Associated Drugs

Milbemycin Oxime + Spinosad 62
Fluralaner Chew Tablets 29
Phenobarbital 26
Spinosad 25
Unspecified 17
Afoxolaner 68 Mg Chewable Tablets 8
Carprofen 6
Afoxolaner 28.3 Mg Chewable Tablets 6
Levetiracetam 5
Trilostane 5
Moxidectin 5
Afoxolaner 136 Mg Chewable Tablets 5
Milbemycin Oxime + Praziquantel 5
Imidacloprid + Moxidectin 4
Ivermectin 4
Levothyroxine Sodium 4
Prednisone 4
Zonisamide 4
Meloxicam 4
Potassium Bromide 3

Epileptic seizure Reaction Insights

205 reports name Epileptic seizure; 16 recorded a death outcome (7.8% of reported events, not a population-level mortality rate). VeDDRA code: 648.

By species: Dog (197 reports), Cat (6 reports), Horse (2 reports). By breed: Retriever - Labrador (20), Terrier - Yorkshire (12), Beagle (11).

Most co-reported drugs: Milbemycin Oxime + Spinosad (62 reports), Fluralaner Chew Tablets (29 reports), Phenobarbital (26 reports), Spinosad (25 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.