Reaction profile

The FDA adverse-event record for elevated red cell distribution width (rdw)

37 FDA adverse-event reports reference elevated red cell distribution width (rdw) (VeDDRA 2857). See the species, breeds, and drugs most associated with it below.

37
reports citing this reaction
35.1%
death-coded share
Dog
most-affected species
Buprenorphine
most-associated drug
Verify with FDA CVM →
37
Total Reports
13
Deaths
35.1%
Death Rate

Species Most Affected

Dog 19
Cat 18

Breeds Most Affected

Domestic Shorthair 11
Retriever - Labrador 4
Domestic Longhair 2
Crossbred Canine/dog 2
Terrier - Bull - Staffordshire 2
Spitz - German Pomeranian 1
Shepherd Dog - German 1
Bulldog - French 1
Sheepdog (unspecified) 1
Siamese 1

Associated Drugs

Buprenorphine 6
Eprinomectin + Esafoxolaner + Praziquantel 5
Propofol 4
Robenacoxib 3
Bedinvetmab 3
Lotilaner 3
Rabies Vaccine, Killed Virus 2
Maropitant Citrate 2
Ketamine 2
Emodepside + Praziquantel 2
Afoxolaner 2
Rabies Vaccine 2
Purevax Feline 3/Rabies - 16T9.R0 2
Purevax Recombinant Felv - 1555.R4 2
Phenobarbital 2
Predisone 2
Diazepam 2
Unspecified Anesthetics 2
Enrofloxacin 1
Canine Distemper-Adenovirus Type 2-Coronavirus-Parvovirus Vaccine, Modified Live And Killed Virus 1

Elevated red cell distribution width (RDW) Reaction Insights

37 reports name Elevated red cell distribution width (RDW); 13 recorded a death outcome (35.1% of reported events, not a population-level mortality rate). VeDDRA code: 2857.

By species: Dog (19 reports), Cat (18 reports). By breed: Domestic Shorthair (11), Retriever - Labrador (4), Domestic Longhair (2).

Most co-reported drugs: Buprenorphine (6 reports), Eprinomectin + Esafoxolaner + Praziquantel (5 reports), Propofol (4 reports), Robenacoxib (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.